Angiotensin-converting enzyme in non-neoplastic kidney diseases

被引:86
作者
Metzger, R
Bohle, RM
Pauls, K
Eichner, G
Alhenc-Gelas, F
Danilov, SM
Franke, FE
机构
[1] Univ Giessen, Dept Pathol, Inst Math, D-35392 Giessen, Germany
[2] Univ Munich, Dept Pediat Surg, Munich, Germany
[3] Univ Illinois, Dept Anesthesiol, Chicago, IL USA
[4] INSERM, U 367, Paris, France
关键词
kidney; endothelium; ACE; CD143; vascular system; interstitium; interstitial fibrosis;
D O I
10.1046/j.1523-1755.1999.00660.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background The angiotensin I-converting enzyme (ACE, CD143, kininase II) plays a critical role in controlling the level of vasoactive peptides such as angiotensins and kinins in the local circulations and tissue interstitium. Because recent work has documented a vessel-, organ-, and species-specific pattern of endothelial ACE expression in the vascular system, we have analyzed whether or not changes of this pattern occur in vessels, tubules, and interstitium of the human kidney that is affected by different non-neoplastic diseases. Methods. Using a set of well-characterized monoclonal antibodies (mAbs), ACE was assessed on renal tissue of 135 patients by immunohistochemistry, including an additional analysis at the ultrastructural level. A semiquantitative evaluation allowed the estimation and comparison of ACE content in different renal compartments. These data were compared with several clinical findings, diagnosis, therapeutic modalities, and histological features. Results. In contrast to the normal human kidney, where ACE is abundant in the brush border of the proximal tubule but is usually absent in endothelial cells of any vessel type, an endothelial neoexpression of ACE was observed in different diseases. In general, this neoexpression was associated with histological sites of interstitial fibrosis and showed some selectivity for glomerular endothelial cells in diabetes mellitus and chronic arterial hypertension. There was also a loss of epithelial ACE in the proximal tubule in certain pathological conditions, for example, in chronic fibroplastic processes, acute pyelonephritis, and different stages of acute renal failure. Conclusions. Neoexpression of ACE by renal endothelial cells, as well as changes of the tubular ACE content, is a common finding in diseased human kidneys. As associated with certain tissue sites, clinical and/or morphological features, these changes may be involved in parenchymal remodeling and renal pathophysiology.
引用
收藏
页码:1442 / 1454
页数:13
相关论文
共 71 条
  • [1] THE ANGIOTENSIN CONVERTING ENZYME IN THE KIDNEY
    ALHENCGELAS, F
    BAUSSANT, T
    HUBERT, C
    SOUBRIER, F
    CORVOL, P
    [J]. JOURNAL OF HYPERTENSION, 1989, 7 : S9 - S14
  • [2] RENAL RENIN-ANGIOTENSIN SYSTEM IN DIABETES - FUNCTIONAL, IMMUNOHISTOCHEMICAL, AND MOLECULAR BIOLOGICAL CORRELATIONS
    ANDERSON, S
    JUNG, FF
    INGELFINGER, JR
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (04): : F477 - F486
  • [3] Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter
    Boll, M
    Herget, M
    Wagener, M
    Weber, WM
    Markovich, D
    Biber, J
    Clauss, W
    Murer, H
    Daniel, H
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) : 284 - 289
  • [4] PROXIMAL TUBULAR SECRETION OF ANGIOTENSIN-II IN RATS
    BRAAM, B
    MITCHELL, KD
    FOX, J
    NAVAR, LG
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (05): : F891 - F898
  • [5] ANGIOTENSIN-II-BINDING SITES IN RAT AND PRIMATE ISOLATED RENAL TUBULAR BASOLATERAL MEMBRANES
    BROWN, GP
    DOUGLAS, JG
    [J]. ENDOCRINOLOGY, 1983, 112 (06) : 2007 - 2014
  • [6] ANGIOTENSIN-I CONVERTING ENZYME IN HUMAN INTESTINE AND KIDNEY - ULTRASTRUCTURAL IMMUNOHISTOCHEMICAL LOCALIZATION
    BRUNEVAL, P
    HINGLAIS, N
    ALHENCGELAS, F
    TRICOTTET, V
    CORVOL, P
    MENARD, J
    CAMILLERI, JP
    BARIETY, J
    [J]. HISTOCHEMISTRY, 1986, 85 (01) : 73 - 80
  • [7] ANGIOTENSIN-CONVERTING ENZYME - VASCULAR ENDOTHELIAL LOCALIZATION
    CALDWELL, PRB
    SEEGAL, BC
    HSU, KC
    DAS, M
    SOFFER, RL
    [J]. SCIENCE, 1976, 191 (4231) : 1050 - 1051
  • [8] EFFECTS OF ANGIOTENSIN-II AND VASOPRESSIN ON HUMAN SMOOTH-MUSCLE CELLS-INVITRO
    CAMPBELLBOSWELL, M
    ROBERTSON, AL
    [J]. EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1981, 35 (02) : 265 - 276
  • [9] NEUTROPHIL-MEDIATED ENDOTHELIAL ANGIOTENSIN-CONVERTING ENZYME DYSFUNCTION - ROLE OF OXYGEN-DERIVED FREE-RADICALS
    CHEN, XL
    CATRAVAS, JD
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (03): : L243 - L249
  • [10] Angiotensin II receptors: Protein and gene structures, expression and potential pathological involvements
    Clauser, E
    Curnow, KM
    Davies, E
    Conchon, S
    Teutsch, B
    Vianello, B
    Monnot, C
    Corvol, P
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1996, 134 (04) : 403 - 411