Connective tissue growth factor (CTGF) and cancer progression

被引：130

作者：

Chu, Chia-Yu ^{[2
,3
]}

Chang, Cheng-Chi ^{[1
,2
]}

Prakash, Ekambaranellore ^{[1
,2
]}

Kuo, Min-Liang ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ, Lab Mol & Cellular Toxicol, Inst Toxicol, Coll Med, Taipei 100, Taiwan

[2] Natl Taiwan Univ, Angiogenesis Res Ctr, Taipei 100, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Dermatol, Taipei 100, Taiwan

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2008年 / 15卷 / 06期

关键词：

Angiogenesis; Anoikis; Cancer; Connective tissue growth factor; CTGF; Invasion; Migration;

D O I：

10.1007/s11373-008-9264-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Connective tissue growth factor (CTGF) is a member of the CCN family of secreted, matrix-associated proteins encoded by immediate early genes that play various roles in angiogenesis and tumor growth. CCN family proteins share uniform modular structure which mediates various cellular functions such as regulation of cell division, chemotaxis, apoptosis, adhesion, motility, angiogenesis, neoplastic transformation, and ion transport. Recently, CTGF expression has been shown to be associated with tumor development and progression. There is growing body of evidence that CTGF may regulate cancer cell migration, invasion, angiogenesis, and anoikis. In this review, we will highlight the influence of CTGF expression on the biological behavior and progression of various cancer cells, as well as its regulation on various types of protein signals and their mechanisms.

引用

页码：675 / 685

页数：11

共 121 条

[1] Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer [J].