TMPRSS2 Is an Activating Protease for Respiratory Parainfluenza Viruses

被引：52

作者：

Abe, Masako ^{[1
]}

Tahara, Maino ^{[1
]}

Sakai, Kouji ^{[1
]}

Yamaguchi, Hiromi ^{[5
]}

Kanou, Kazuhiko ^{[2
]}

Shirato, Kazuya ^{[1
]}

Kawase, Miyuki ^{[1
]}

Noda, Masahiro ^{[1
,2
]}

Kimura, Hirokazu ^{[2
]}

Matsuyama, Shutoku ^{[1
]}

Fukuhara, Hideo ^{[6
]}

Mizuta, Katsumi ^{[4
]}

Maenaka, Katsumi ^{[6
]}

Ami, Yasushi ^{[3
]}

Esumi, Mariko ^{[5
]}

Kato, Atsushi ^{[1
]}

Takeda, Makoto ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Virol 3, Tokyo, Japan

[2] Natl Inst Infect Dis, Infect Dis Surveillance Ctr, Tokyo, Japan

[3] Natl Inst Infect Dis, Div Expt Anim Res, Tokyo, Japan

[4] Yamagata Prefectural Inst Publ Hlth, Yamagata 9900031, Japan

[5] Nihon Univ, Sch Med, Dept Pathol, Itabashi Ku, Tokyo, Japan

[6] Hokkaido Univ, Fac Pharmaceut Sci, Lab Biomol Sci, Sapporo, Hokkaido 060, Japan

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 21期

关键词：

INFLUENZA-A VIRUSES; FLUOROGENIC PEPTIDE MICROARRAYS; CORONAVIRUS SPIKE PROTEIN; HUMAN AIRWAY EPITHELIUM; TRYPSIN-LIKE PROTEASE; SENDAI-VIRUS; SERINE PROTEASES; PROTEOLYTIC ACTIVATION; SUBSTRATE-SPECIFICITY; TRIGGERS INFECTION;

D O I：

10.1128/JVI.01490-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here, we show that human parainfluenza viruses and Sendai virus (SeV), like other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion proteins of respiratory viruses often possess serine and glutamine residues at the P2 and P3 positions, respectively, but these residues were not critical for cleavage by TMPRSS2. However, mutations of these residues affected SeV growth in specific epithelial cell lines, suggesting the importance of these residues for SeV replication in epithelia.

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收藏

页码：11930 / 11935

页数：6

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