Interventions for preventing critical illness polyneuropathy and critical illness myopathy

被引:128
作者
Hermans, Greet [1 ]
De Jonghe, Bernard [2 ]
Bruyninckx, Frans [3 ]
Van den Berghe, Greet [4 ]
机构
[1] Katholieke Univ Leuven, Dept Cellular & Mol Med, B-3000 Leuven, Belgium
[2] Ctr Hosp Poissy St Germain, Poissy, France
[3] Katholieke Univ Leuven, Univ Hosp, B-3000 Leuven, Belgium
[4] Katholieke Univ Leuven, Dept Intens Care Med, Univ Hosp, B-3000 Leuven, Belgium
来源
COCHRANE DATABASE OF SYSTEMATIC REVIEWS | 2014年 / 01期
基金
欧洲研究理事会;
关键词
Adrenal Cortex Hormones [therapeutic use; Human Growth Hormone [therapeutic use; Hypoglycemia [chemically induced; Hypoglycemic Agents [adverse effects therapeutic use; Insulin [adverse effects therapeutic use; Length of Stay [statistics & numerical data; Muscular Diseases [mortality; *prevention & control; Polyneuropathies [mortality; Randomized Controlled Trials as Topic Recombinant Proteins [therapeutic use; Respiration; Artificial [utilization; INTENSIVE INSULIN THERAPY; ELECTRICAL MUSCLE STIMULATION; OBSTRUCTIVE PULMONARY-DISEASE; HUMAN GROWTH-HORMONE; BETA-METHYLBUTYRATE SUPPLEMENTATION; UNIT-ACQUIRED WEAKNESS; MULTIPLE ORGAN FAILURE; CARE-UNIT; RISK-FACTORS; NUTRITIONAL SUPPORT;
D O I
10.1002/14651858.CD006832.pub3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Critical illness polyneuropathy or myopathy (CIP/CIM) is a frequent complication in the intensive care unit (ICU) and is associated with prolonged mechanical ventilation, longer ICU stay and increased mortality. This is an interim update of a review first published in 2009 (Hermans 2009). It has been updated to October 2011, with further potentially eligible studies from a December 2013 search characterised as awaiting assessment. Objectives To systematically review the evidence from RCTs concerning the ability of any intervention to reduce the incidence of CIP or CIM in critically ill individuals. Search methods On 4 October 2011, we searched the Cochrane Neuromuscular Disease Group Specialized Register, CENTRAL, MEDLINE, and EMBASE. We checked the bibliographies of identified trials and contacted trial authors and experts in the field. We carried out an additional search of these databases on 6 December 2013 to identify recent studies. Selection criteria All randomised controlled trials (RCTs), examining the effect of any intervention on the incidence of CIP/CIM in people admitted to adult medical or surgical ICUs. The primary outcome was the incidence of CIP/CIM in ICU, based on electrophysiological or clinical examination. Secondary outcomes included duration of mechanical ventilation, duration of ICU stay, death at 30 and 180 days after ICU admission and serious adverse events from the treatment regimens.
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