The exosome and the proteasome: Nano-compartments for degradation

被引：63

作者：

Lorentzen, Esben

Conti, Elena

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

[2] Max Planck Inst Biochem, D-82152 Martinsried, Germany

来源：

CELL | 2006年 / 125卷 / 04期

关键词：

D O I：

10.1016/j.cell.2006.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exosomes and proteasomes are macromolecular complexes that posttranscriptionally regulate gene expression by degrading mRNAs and proteins, respectively. Although the two complexes act on different substrates and are composed of different subunits, they share a similar barrel-like architecture that appears to have evolved to restrict substrate access and prevent indiscriminate degradation.

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收藏

页码：651 / 654

页数：4

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