Increased cardiovascular risk and premature atherosclerosis in rheumatoid arthritis

被引：6

作者：

Akrout, R. ^{[1
]}

Fourati, H. ^{[1
]}

Mnif, E. ^{[2
]}

Ben Mahfoudh, K. H. ^{[3
]}

Hachicha, I. ^{[1
]}

Ezzeddine, M. ^{[1
]}

Ayedi, F. ^{[2
]}

Mnif, J. ^{[3
]}

Baklouti, S. ^{[1
]}

机构：

[1] CHU Hedi Chaker, Serv Rhumatol, Sfax, Tunisia

[2] CHU Habib Bourguiba, Biochim Lab, Sfax, Tunisia

[3] CHU Habib Bourguiba, Serv Imagerie Med, Sfax, Tunisia

来源：

ANNALES DE CARDIOLOGIE ET D ANGEIOLOGIE | 2012年 / 61卷 / 04期

关键词：

Rheumatoid arthritis; Cardiovascular disease; Atherosclerosis; MORTALITY; DISEASE; GLUCOCORTICOIDS; METHOTREXATE; LIPOPROTEIN; MORBIDITY;

D O I：

10.1016/j.ancard.2012.04.009

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Patients with rheumatoid arthritis (RA) are at increased risk of mortality compared with the general population. Evidence suggests that this increased mortality can largely be attributed to increased cardiovascular (CV) death. In a prospective study, 34 patients with RA were compared with age- and sex-matched controls. Results. - We found a lower C-HDL, apolipoprotein Al and B in patients with RA. However, CT/C-HDL and C-LDL/C-HDL were significantly higher than control patients. The intima-media thickness was significantly higher in patients with RA (0.759 mm vs 0.558 rum; P<0.001). Conclusion. - Increased attention to cardiovascular risk in RA will be necessary to reduce the excess CV mortality and morbidity in RA patients. It appears that the excess risk that is observed in the RA population can be explained, in part, by promotion of CV disease through increased systemic inflammation associated with RA. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：267 / 273

页数：7

共 29 条

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