Heterotopic ossification after the use of commercially available recombinant human bone morphogenetic proteins in four patients

被引：66

作者：

Axelrad, T. W. ^{[1
]}

Steen, B. ^{[1
]}

Lowenberg, D. W. ^{[2
]}

Creevy, W. R. ^{[1
]}

Einhorn, T. A. ^{[1
]}

机构：

[1] Boston Univ, Med Ctr, Dept Orthopaed Surg, Boston, MA 02118 USA

[2] Calif Pacific Med Ctr, San Francisco, CA 94115 USA

来源：

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME | 2008年 / 90B卷 / 12期

关键词：

D O I：

10.1302/0301-620X.90B12.20975

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Heterotopic ossification occurring after the use of commercially available bone morphogenetic proteins has not been widely reported. We describe four cases of heterotopic ossification in patients treated with either recombinant bone morphogenetic protein 2 or recombinant bone morphogenetic protein 7. We found that while some patients were asymptomatic, heterotopic ossification which had occurred around a joint often required operative excision with good results.

引用

页码：1617 / 1622

页数：6

共 50 条

[1]

AHRENGART L, 1991, CLIN ORTHOP RELAT R, V263, P49

[2] New technologies for the enhancement of skeletal repair [J].

Axelrad, T. William ;

Kakar, Sanjeev ;

Einhorn, Thomas A. .

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2007, 38 :S49-S62

[3] The prophylaxis and treatment of heterotopic ossification following lower limb arthroplasty [J].

Board, T. N. ;

Karva, A. ;

Board, R. E. ;

Gambhir, A. K. ;

Porter, M. L. .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2007, 89B (04) :434-440

[4] Intramedullary application of bone morphogenetic protein in the management of a major bone defect after an Ilizarov procedure [J].

Burkhart, K. J. ;

Rommens, P. M. .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2008, 90B (06) :806-809

[5] Calcium deposition with or without bone formation in the lung [J].

Chan, ED ;

Morales, DV ;

Welsh, CH ;

McDermott, MT ;

Schwarz, MI .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 165 (12) :1654-1669

[6] Synergistic effects of Nell-1 and BMP-2 on the osteogenic differentiation of myoblasts [J].

Cowan, Catherine M. ;

Jiang, Xinquan ;

Hsu, Tiffany ;

Soo, Chia ;

Zhang, Beiji ;

Wang, Joyce Z. ;

Kuroda, Shun'ichi ;

Wu, Benjamin ;

Zhang, Zhiyuan ;

Zhang, Xinli ;

Ting, Kang .

JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (06) :918-930

[7] Application of recombinant BMP-7 on persistent upper and lower limb non-unions [J].

Dimitriou, R ;

Dahabreh, Z ;

Katsoulis, E ;

Matthews, SJ ;

Branfoot, T ;

Giannoudis, PV .

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2005, 36 :S51-S59

[8] Surgical treatment of intra-articular fractures of the distal part of the humerus [J].

Doornberg, Job N. ;

van Duijn, Pleun J. ;

Linzel, Durk ;

Ring, David C. ;

Zurakowski, David ;

Marti, Rene K. ;

Kloen, Peter .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2007, 89A (07) :1524-1532

[9] Systemic effects of severe trauma on the function and apoptosis of human skeletal cells [J].

Eid, K. ;

Labler, L. ;

Ertel, W. ;

Trentz, O. ;

Keel, M. .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2006, 88B (10) :1394-1400

[10] C-reaction protein and erythrocyte sedimentation rate in patients with heterotopic ossification after spinal cord injury [J].

Estrores, IM ;

Harrington, A ;

Banovac, K .

JOURNAL OF SPINAL CORD MEDICINE, 2004, 27 (05) :434-437

← 1 2 3 4 5 →