Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice

被引：82

作者：

Caldwell, H. K. ^{[1
]}

Stephens, S. I. ^{[1
]}

Young, W. S., III ^{[1
]}

机构：

[1] NIMH, Sect Neural Gene Express, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

来源：

MOLECULAR PSYCHIATRY | 2009年 / 14卷 / 02期

关键词：

psychotomimetics; prepulse inhibition; sensorimotor gating; schizophrenia; phencyclidine; OBSESSIVE-COMPULSIVE DISORDER; STARTLE GATING DEFICITS; PREPULSE INHIBITION DEFICITS; LOW-DOSE KETAMINE; SCHIZOPHRENIC-PATIENTS; ACOUSTIC STARTLE; CEREBROSPINAL-FLUID; TOURETTES-SYNDROME; NEUROLEPTIC MEDICATION; HABITUATION DEFICITS;

D O I：

10.1038/sj.mp.4002150

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been previously suggested that oxytocin (Oxt) may act as a natural antipsychotic. To test this hypothesis, we investigated whether disruption of the oxytocin gene (Oxt-/-) made mice more susceptible to the psychosis-related effects of amphetamine (Amp), apomorphine (Apo) and phencyclidine (PCP). We examined drug-induced changes in the prepulse inhibition (PPI) of the startle reflex, a measure of sensorimotor gating deficits characteristic of several psychiatric and neurological disorders, including schizophrenia. We found that treatment with Amp, Apo and PCP all had effects on PPI. However, in Oxt-/- mice, but not Oxt-/- mice, PCP treatment resulted in large PPI deficits. As PCP is a noncompetitive N-methyl-D-aspartic acid receptor antagonist, these findings suggest that the absence of Oxt alters the glutamatergic component of the PPI.

引用

页码：190 / 196

页数：7

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