Polypeptide release factors in prokaryotes and eukaryotes: Same function, different structure

被引:13
作者
Kisselev, L [1 ]
机构
[1] VA Engelhardt Mol Biol Inst, Moscow 119991, Russia
关键词
D O I
10.1016/S0969-2126(01)00703-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Although the eukaryotic (eRF1) and prokaryotic (RF2) polypeptide release (translation termination) factors are functionally similar, they turn out to be very different in overall shape and architecture and in the location of key functional elements.
引用
收藏
页码:8 / 9
页数:2
相关论文
共 9 条
[1]   Terminating eukaryote translation: Domain 1 of release factor eRF1 functions in stop codon recognition [J].
Bertram, G ;
Bell, HA ;
Ritchie, DW ;
Fullerton, G ;
Stansfield, I .
RNA, 2000, 6 (09) :1236-1247
[2]   A HIGHLY CONSERVED EUKARYOTIC PROTEIN FAMILY POSSESSING PROPERTIES OF POLYPEPTIDE-CHAIN RELEASE FACTOR [J].
FROLOVA, L ;
LEGOFF, X ;
RASMUSSEN, HH ;
CHEPEREGIN, S ;
DRUGEON, G ;
KRESS, M ;
ARMAN, I ;
HAENNI, AL ;
CELIS, JE ;
PHILIPPE, M ;
JUSTESEN, J ;
KISSELEV, L .
NATURE, 1994, 372 (6507) :701-703
[3]   Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis [J].
Frolova, LY ;
Tsivkovskii, RY ;
Sivolobova, GF ;
Oparina, NY ;
Serpinsky, OI ;
Blinov, VM ;
Tatkov, SI ;
Kisselev, LL .
RNA, 1999, 5 (08) :1014-1020
[4]   A tripeptide 'anticodon' deciphers stop codons in messenger RNA [J].
Ito, K ;
Uno, M ;
Nakamura, Y .
NATURE, 2000, 403 (6770) :680-684
[5]   Stop codon recognition in ciliates:: Euplotes release factor does not respond to reassigned UGA codon [J].
Kervestin, S ;
Frolova, L ;
Kisselev, L ;
Jean-Jean, O .
EMBO REPORTS, 2001, 2 (08) :680-684
[6]   Mimicry grasps reality in translation termination [J].
Nakamura, Y ;
Ito, K ;
Ehrenberg, M .
CELL, 2000, 101 (04) :349-352
[7]   Class-1 translation termination factors: invariant GGQ minidomain is essential for release activity and ribosome binding but not for stop codon recognition [J].
Seit-Nebi, A ;
Frolova, L ;
Justesen, J ;
Kisselev, L .
NUCLEIC ACIDS RESEARCH, 2001, 29 (19) :3982-3987
[8]   The crystal structure of human eukaryotic release factor eRF1 - Mechanism of stop codon recognition and peptidyl-tRNA hydrolysis [J].
Song, HW ;
Mugnier, P ;
Das, AK ;
Webb, HM ;
Evans, DR ;
Tuite, MF ;
Hemmings, BA ;
Barford, D .
CELL, 2000, 100 (03) :311-321
[9]   Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1 [J].
Vestergaard, B ;
Van, LB ;
Andersen, GR ;
Nyborg, J ;
Buckingham, RH ;
Kjeldgaard, M .
MOLECULAR CELL, 2001, 8 (06) :1375-1382