Probiotics and irritable bowel syndrome

被引:18
作者
Camilleri, Michael [1 ,2 ,3 ]
机构
[1] Mayo Clin, Coll Med, Dept Med, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Dept Physiol, Rochester, MN 55905 USA
[3] Mayo Clin, Div Gastroenterol, Rochester, MN 55905 USA
关键词
probiotics; irritable bowel syndrome; inflammation; secretion; sensation; fermentation; immune function;
D O I
10.1097/MCG.0b013e3181574393
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
To review the rationale and current evidence for the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS), the following specific questions are addressed from a review of the published literature: Are bacterial flora altered in IBS? Is infection a significant risk factor for IBS? How prominent is the inflammation in IBS? Do probiotics change bacterial flora? Do probiotics adhere to mucosa? What are the potential mechanisms of action of probiotics in IBS: immune function, motor, secretory, sensory, and fermentation? What is the efficacy of probiotics in IBS?
引用
收藏
页码:S123 / S125
页数:3
相关论文
共 20 条
[1]   Lactobacillus farciminis treatment suppresses stress induced visceral hypersensitivity:: a possible action through interaction with epithelial cell cytoskeleton contraction [J].
Ait-Belgnaoui, A. ;
Han, W. ;
Lamine, F. ;
Eutamene, H. ;
Fioramonti, J. ;
Bueno, L. ;
Theodorou, V. .
GUT, 2006, 55 (08) :1090-1094
[2]   The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells [J].
Caballero-Franco, C. ;
Keller, K. ;
De Simone, C. ;
Chadee, K. .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2007, 292 (01) :G315-G322
[3]  
CHRISTL SU, 1992, GASTROENTEROLOGY, V102, P1269
[4]  
GAREAU MG, 2007, GUT
[5]   Postinfectious irritable bowel syndrome - A meta-analysis [J].
Halvorson, Heather A. ;
Schlett, Carey D. ;
Riddle, Mark S. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2006, 101 (08) :1894-1899
[6]   Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats [J].
Husebye, E ;
Hellström, PM ;
Sundler, F ;
Chen, J ;
Midtvedt, T .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 280 (03) :G368-G380
[7]   A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating [J].
Kim, HJ ;
Roque, MIV ;
Camilleri, M ;
Stephens, D ;
Burton, DD ;
Baxter, K ;
Thomforde, G ;
Zinsmeister, AR .
NEUROGASTROENTEROLOGY AND MOTILITY, 2005, 17 (05) :687-696
[8]   A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome [J].
Kim, HJ ;
Camilleri, M ;
McKinzie, S ;
Lempke, MB ;
Burton, DD ;
Thomforde, GM ;
Zinsmeister, AR .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2003, 17 (07) :895-904
[9]   Abnormal colonic fermentation in irritable bowel syndrome [J].
King, TS ;
Elia, M ;
Hunter, JO .
LANCET, 1998, 352 (9135) :1187-1189
[10]   Probiotic bacteria enhance murine and human intestinal epithelial barrier function [J].
Madsen, K ;
Cornish, A ;
Soper, P ;
McKaigney, C ;
Jijon, H ;
Yachimec, C ;
Doyle, J ;
Jewell, L ;
De Simone, C .
GASTROENTEROLOGY, 2001, 121 (03) :580-591