Estrogenicity of resin-based composites and sealants used in dentistry

被引:531
作者
Olea, N
Pulgar, R
Perez, P
OleaSerrano, F
Rivas, A
NovilloFertrell, A
Pedraza, V
Soto, AM
Sonnenschein, C
机构
[1] UNIV GRANADA, SCH DENT, DEPT MED ODONTOL, E-18071 GRANADA, SPAIN
[2] UNIV GRANADA, SCH PHARM, DEPT NUTR, E-18071 GRANADA, SPAIN
[3] TUFTS UNIV, SCH MED, DEPT ANAT & CELLULAR BIOL, BOSTON, MA 02111 USA
关键词
bisphenol-A; composite resins and sealants; E-screen bioassay; restorative dentistry; xenoestrogens;
D O I
10.2307/3432888
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
We tested some resin-based composites used in density for their estrogenic activity. A sealant based on bisphenol-A diglycidylether methacrylate (bis-GMA) increased cell yields, progesterone receptor expression, and pS2 secretion in human estrogen-target, serum-sensitive MCF7 breast cancer cells. Estrogenicity was clue to bisphenol-A and bisphenol-A dimethacrylate, monomers found in the base paste of the dental sealant and identified by mass spectrometry. Samples of saliva from 18 subjects treated with 50 mg of a bis-GMA-based sealant applied on their molars were collected 1 hr before and after treatment. Bisphenol-A (range 90-931 mu g) was identified only in saliva collected during a 1-hr period after treatment. The use of bis-GMA-based resins in dentistry, and particularly the use of sealants in children, appears to contribute to human exposure to xenoestrogens.
引用
收藏
页码:298 / 305
页数:8
相关论文
共 36 条