Focal destruction and remodeling in guinea pig arthrosis

被引:29
作者
deBri, E
Jonsson, K
Reinholt, FP
Svensson, O
机构
[1] KAROLINSKA INST, HUDDINGE HOSP, DEPT PATHOL, S-14186 HUDDINGE, SWEDEN
[2] KAROLINSKA INST, HUDDINGE HOSP, CLIN RES CTR, S-14186 HUDDINGE, SWEDEN
来源
ACTA ORTHOPAEDICA SCANDINAVICA | 1996年 / 67卷 / 05期
关键词
D O I
10.3109/17453679608996676
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
We investigated the proximal tibiae in adult, middle-aged and old (6, 12, and 30 months) guinea pigs with spontaneous arthrosis by quantitative morphometry. Since the cartilage destruction develops predominantly in the medial tibial plateau, the lateral side may serve as an internal control. In established lesions, cartilage destructions were focal, surrounded by a brim of thickened cartilage that was grossly intact, but showed cell clustering, hypertrophy and increased metachromasia. Peripherally, there was a distinct transition to normal-appearing cartilage, Subjacent to the cartilage ulcerations, subchondral bone was thickened. Compared to the lateral plateau the height of the calcified cartilage increased and the surface density of the osteocartilaginous interface decreased. Marrow depletion and cysts developed below the cartilage ulcerations. Cysts seem to develop through fibrous issue partially undergoing cartilage metaplasia in tiny noduli that subsequently coalesce, liquefy centrally and expand. Superficially, similar fibrocartilaginous proliferations result in incomplete resurfacing and small areas of subchondral resorption; in the periphery of the joint, they form osteophytes. In the guinea pig, arthrosis tissue destruction is thus accompanied by local tissue proliferation.
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收藏
页码:498 / 504
页数:7
相关论文
共 29 条
[1]
ADAMS ME, 1982, CURR TOPICS PATHOL, V71, P265
[2]
INDEPENDENT EXPRESSION OF FIBRIL-FORMING COLLAGEN-I, COLLAGEN-II, AND COLLAGEN-III IN CHONDROCYTES OF HUMAN OSTEOARTHRITIC CARTILAGE [J].
AIGNER, T ;
BERTLING, W ;
STOSS, H ;
WESELOH, G ;
VONDERMARK, K .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (03) :829-837
[3]
ANDERSON DD, 1993, CLIN ORTHOP RELAT R, V286, P298
[4]
ARNOLDI C C, 1972, Journal of Bone and Joint Surgery British Volume, V54B, P409
[5]
ESTIMATION OF SURFACE-AREA FROM VERTICAL SECTIONS [J].
BADDELEY, AJ ;
GUNDERSEN, HJG ;
CRUZORIVE, LM .
JOURNAL OF MICROSCOPY-OXFORD, 1986, 142 :259-276
[6]
BENDELE AM, 1989, LAB ANIM SCI, V39, P115
[7]
Bennett GA, 1937, J BONE JOINT SURG, V19, P667
[8]
CAMERON HU, 1975, CLIN ORTHOP RELAT R, V111, P266
[9]
Collins D., 1949, PATHOLOGY ARTICULAR
[10]
PRIMARY OSTEOARTHROSIS IN GUINEA-PIGS - A STEREOLOGICAL STUDY [J].
DEBRI, E ;
REINHOLT, FP ;
SVENSSON, O .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1995, 13 (05) :769-776