Regional distribution of parkinsonism-preventing endogenous tetrahydroisoquinoline derivatives and an endogenous parkinsonism-preventing substance-synthesizing enzyme in monkey brain

被引：51

作者：

Yamakawa, T

Kotake, Y

Fujitani, M

Shintani, H

Makino, Y

Ohta, S

机构：

[1] Hiroshima Univ, Sch Med, Inst Pharmaceut Sci, Minami Ku, Hiroshima 7348551, Japan

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1138605, Japan

[3] Hiroshima Univ, Sch Dent, Dept Operat Dent, Minami Ku, Hiroshima 7348551, Japan

来源：

NEUROSCIENCE LETTERS | 1999年 / 276卷 / 01期

关键词：

parkinsonism; 1-methyl-1,2,3,4-tetrahydroisoquinoline-synthesizing enzyme; monkey brain; endogenous tetrahydroisoquinolines; regional distribution in brain; 1-benzyl-1,2,3,4-tetrahydroisoquinoline;

D O I：

10.1016/S0304-3940(99)00786-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

1,2,3,4-Tetrahydroisoquinoline (TIQ) and 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), which exist in the brain of several mammalian species, are parkinsonism-inducing substances, and 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), which is enzymatically synthesized in rat brain, is a parkinsonism-preventing substance. in this study, we examined the regional distribution of contents of TIQ, 1MeTIQ, and 1BnTIQ, and activity of 1MeTIQ-synthesizing enzyme in monkey brain. The TIQ and 1BnTIQ contents in cerebrum and substantia nigra, and the 1MeTIQ contents in striatum and substantia nigra were higher than those in other brain regions, and 1MeTIQ-synthetic activity was high in cerebrum and thalamus. We speculate that 1MeTIQ-synthesizing enzyme may play an important role in idiopathic Parkinson's disease. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：68 / 70

页数：3

共 16 条

[1] INDOLE-N-METHYLATED BETA-CARBOLINIUM IONS AS POTENTIAL BRAIN-BIOACTIVATED NEUROTOXINS [J].