p63 and epithelial biology

被引：104

作者：

Barbieri, CE ^{[1
]}

Pietenpol, JA ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Dept Biochem,Ctr Mol Toxicol, Nashville, TN 37232 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2006年 / 312卷 / 06期

关键词：

p53; keratinocytes; differentiation; transcription; cancer; target genes;

D O I：

10.1016/j.yexcr.2005.11.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The transcription factor p63 is a homologue of the tumor suppressor p53. Unlike p53, which is dispensable for normal development, p63 is critical for the development of stratified epithelial tissues such as epidermis, breast, and prostate. p63 encodes multiple protein isoforms with both transactivating and transcriptional repressor activities that can regulate a wide spectrum of target genes. p63 is also implicated in tumor formation and progression in stratified epithelia, with evidence for both tumor suppressive and oncogenic properties. This review will examine current data and hypotheses regarding the role of p63 in the development, maintenance, and tumorigenesis of stratified epithelium. (c) 2005 Published by Elsevier Inc.

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收藏

页码：695 / 706

页数：12

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