Comparison of four homologous retention index standard series for qualitative gas chromatography of nitrogenous acidic and neutral drugs

被引：7

作者：

Rasanen, I ^{[1
]}

Ojanpera, I ^{[1
]}

Vuori, E ^{[1
]}

Hase, TA ^{[1
]}

机构：

[1] HELSINKI UNIV,DEPT CHEM,FIN-00014 HELSINKI,FINLAND

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 738卷 / 02期

关键词：

retention indices; alkylmethylhydantoins; alkylhydantoins; alkylmaleimides; alkylbis(trifluoromethyl)phosphine sulphides; drugs; drug screening; capillary gas chromatography;

D O I：

10.1016/0021-9673(96)00095-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Four homologous retention index standard series, the alkylmethylhydantoins, alkylhydantoins, alkylmaleimides and alkylbis(trifluoromethyl)phosphine sulphides, were evaluated for the screening of blood samples for acidic and neutral drugs on Ultra 2 and HP-1701 capillary columns over a six-month period. An index series consisting of actual drug substances was used as a standard of comparison. All the series produced high precision, and the precision differences between the series were rather small. Considering the limitations of the other series, the alkylmethylhydantoins and alkylhydantoins turned out to be the most feasible internal retention index standard series in the present dual column setting.

引用

页码：233 / 239

页数：7

共 14 条

[1]

BLOMBERG LG, 1987, ADV CHROMATOGR, V26, P229

[2]

BRAISH TF, 1992, SYNLETT, V2, P979

[3] RETENTION INDEXES BY WIDE-BORE CAPILLARY GAS-CHROMATOGRAPHY WITH NITROGEN-PHOSPHORUS DETECTION [J].