Proteomics in malaria

被引：26

作者：

Johnson, JR ^{[1
]}

Florens, L ^{[1
]}

Carucci, DJ ^{[1
]}

Yates, JR ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

来源：

JOURNAL OF PROTEOME RESEARCH | 2004年 / 3卷 / 02期

关键词：

malaria; Plasmodium falciparum; proteomics; mass spectrometry;

D O I：

10.1021/pr0340781

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The recent completion of human, Anopheles gambiae, and Plasmodium falciparum genomes relevant to the study of human malaria allows the application of modern proteomic technologies to complement previously implemented conventional approaches. Proteomic analysis has been employed to elucidate global protein expression profiles, subcellular localization of gene products, and host-pathogen interactions that are central to disease pathogenesis and treatment. The high-throughput nature of these techniques is in accord with the pace of drug and vaccine development that have the potential to directly reduce the morbidity and mortality of disease.

引用

页码：296 / 306

页数：11

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