Rhodium-catalyzed addition of arylboronic acids to isatins: An entry to diversity in 3-aryl-3-hydroxyoxindoles

被引：178

作者：

Toullec, Patrick Y.

Jagt, Richard B. C.

de Vries, Johannes G.

Feringa, Ben L.

Minnaard, Adriaan J.

机构：

[1] DSM Res & Patents, Life Sci Adv Synth & Catalysis, NL-6160 MD Geleen, Netherlands

[2] Univ Groningen, Stratingh Inst, Dept Organ & Mol Inorgan Chem, NL-9747 AG Groningen, Netherlands

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 13期

关键词：

D O I：

10.1021/ol0608101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general method for the catalytic 1,2-addition of aryl and alkenyl boronic acids to isatins is described using a rhodium(I)/triphenylphosphite catalyst. The application of this transformation allows the synthesis of a variety of 3-aryl-3-hydroxyoxindole building blocks in high yields. An enantioselective version of this reaction using a rhodium(I)/phosphoramidite system is also presented.

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页码：2715 / 2718

页数：4

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