Drugs mediating myocardial protection

被引：21

作者：

De Hert, Stefan G. ^{[1
]}

Preckel, Benedikt ^{[1
]}

Hollmann, Markus W. ^{[1
]}

Schlack, Wolfgang S. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Anesthesiol, NL-1100 DD Amsterdam, Netherlands

来源：

EUROPEAN JOURNAL OF ANAESTHESIOLOGY | 2009年 / 26卷 / 12期

关键词：

myocardial ischaemia; myocardial reperfusion injury; outcome; pharmacological treatment; postconditioning; preconditioning; ARTERY-BYPASS-SURGERY; ISCHEMIA-REPERFUSION INJURY; GLUCOSE-INSULIN-POTASSIUM; MITOCHONDRIAL PERMEABILITY TRANSITION; RANDOMIZED CONTROLLED-TRIAL; ADULT CARDIAC-SURGERY; ISOLATED RAT-HEART; DECREASES BIOCHEMICAL MARKERS; PERIOPERATIVE STATIN UPDATE; HIGH-RISK PATIENTS;

D O I：

10.1097/EJA.0b013e32832fad8b

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

The occurrence of myocardial ischaemia will result in either reversible or irreversible myocardial dysfunction. Even when revascularization is successful, some reperfusion injury may occur that transiently impairs myocardial function. Therefore, treatment should not only be directed towards prompt restoration of myocardial blood flow but measures should also be taken to prevent or alleviate the consequences of myocardial reperfusion injury. Over the years, various strategies have been developed. The present contribution reviews a number of these strategies focusing on pharmacological treatments that have been developed to address myocardial reperfusion injury. Eur J Anaesthesiol 26: 985-995 (C) 2009 European Society of Anaesthesiology.

引用

页码：985 / 995

页数：11

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