Internal derivatization of oligonucleotides with selenium for X-ray crystallography using MAD

被引：83

作者：

Du, Q

Carrasco, N

Teplova, M

Wilds, CJ

Egli, M

Huang, Z

机构：

[1] CUNY Brooklyn Coll, Dept Chem, Brooklyn, NY 11210 USA

[2] CUNY, Grad Sch, Program Biochem & Chem, Brooklyn, NY 11210 USA

[3] Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37235 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 01期

关键词：

D O I：

10.1021/ja0171097

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a route for the synthesis of 2′-selenium uridine analogues and oligonucleotides containing selenium labels, and have demonstrated for the first time a new strategy to covalently derivatize nucleotides with selenium for phase and structure determination in X-ray crystallography. Copyright © 2002 American Chemical Society.

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页码：24 / 25

页数：2

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