Physicochemical and rheological properties of a novel monoolein-based vesicle gel

被引：30

作者：

Angelico, Ruggero ^{[3
,4
]}

Carboni, Maura ^{[1
,2
]}

Lampis, Sandrina ^{[1
,2
]}

Schmidt, Judith ^{[5
]}

Talmon, Yeshayahu ^{[5
]}

Monduzzi, Maura ^{[1
,2
]}

Murgia, Sergio ^{[1
,2
]}

机构：

[1] Univ Cagliari, Dept Chem & Geol Sci, CNBS, I-09042 Monserrato, CA, Italy

[2] Univ Cagliari, Dept Chem & Geol Sci, CSGI, I-09042 Monserrato, CA, Italy

[3] Univ Molise DIAAA, I-86100 Campobasso, CB, Italy

[4] CSGI, I-86100 Campobasso, CB, Italy

[5] Technion Israel Inst Technol, Dept Chem Engn, IL-32000 Haifa, Israel

来源：

SOFT MATTER | 2013年 / 9卷 / 03期

关键词：

VESICULAR PHOSPHOLIPID GELS; BEHAVIOR; STABILITY; SYSTEM;

D O I：

10.1039/c2sm27215f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

The present paper deals with the preparation and characterization of an innovative vesicle-based gel composed of monoolein and lauroylcholine chloride. A number of vesicular formulations were prepared, in the range of 4-14 wt% of the dispersed phase, to investigate the system evolution from a dilute uni-lamellar vesicle dispersion to a vesicle lipid gel. Morphology, thermal stability up to 55 degrees C, and viscoelastic properties, along with the effect of acid diclofenac inclusion within the formulation, were evaluated by cryo-TEM, SAXS, and rheological measurements. Moreover, the nanostructure of the vesicle dispersion obtained upon gel dilution in water was assessed by cryo-TEM and SAXS, while DLS was used to monitor the formulation stability (size and zeta-potential). All the collected results lead to the conclusion that this new vesicle-based gel displays all the requirements needed for application in the pharmaceutical and cosmetic fields.

引用

页码：921 / 928

页数：8

共 32 条

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