Loss of expression of the p16 gene is frequent in malignant skin tumors

被引：24

作者：

Chang, TG

Wang, JS

Chen, LW

Hsu, CY

Chang, HW

Chen, JS

Cho, CL

机构：

[1] VET GEN HOSP,DEPT PATHOL,KAOHSIUNG 813,TAIWAN

[2] VET GEN HOSP,DIV PLAST & RECONSTRUCT SURG,DEPT SURG,KAOHSIUNG 813,TAIWAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 230卷 / 01期

关键词：

D O I：

10.1006/bbrc.1996.5891

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of the pie gene from 30 malignant skin tumors has been surveyed by immunohistochemical assay. Gene point mutations were detected by DNA direct sequencing and the mRNA level of gene expression was measured by RT-PCR. A silent point mutation of the pie gene was found in only one patient. However, loss of expression of the pie gene was noticed in 23 of 29 samples (79.3%). Correlation between loss of expression of the pie gene and metastasis is significant (p = 0.0036). These findings suggest that loss of expression of the pie gene may play a critical role in tumor progression of malignant skin tumors. (C) 1997 Academic Press

引用

页码：85 / 88

页数：4

共 23 条

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