Characterization of three H5N5 and one H5N8 highly pathogenic avian influenza viruses in China

被引：226

作者：

Zhao, Kunkun ^{[1
]}

Gu, Min ^{[1
,2
]}

Zhong, Lei ^{[1
]}

Duan, Zhiqiang ^{[1
]}

Zhang, Yan ^{[1
]}

Zhu, Yanmei ^{[1
]}

Zhao, Guo ^{[1
]}

Zhao, Mingjun ^{[1
]}

Chen, Zhaoyang ^{[1
]}

Hu, Shunlin ^{[1
,2
]}

Liu, Wenbo ^{[1
,2
]}

Liu, Xiaowen ^{[1
,2
]}

Peng, Daxin ^{[1
,2
]}

Liu, Xiufan ^{[1
,2
]}

机构：

[1] Yangzhou Univ, Coll Vet Med, Anim Infect Dis Lab, Yangzhou 225009, Peoples R China

[2] Yangzhou Univ, Minist Educ, Key Lab Avian Prevent Med, Yangzhou 225009, Peoples R China

来源：

VETERINARY MICROBIOLOGY | 2013年 / 163卷 / 3-4期

关键词：

Avian influenza virus; H5N5; H5N8; Reassortant; RECEPTOR-BINDING; HEMAGGLUTININ; SPECIFICITY; DUCKS;

D O I：

10.1016/j.vetmic.2012.12.025

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

One H5N8 and three H5N5 highly pathogenic avian influenza (HPAI) viruses which derived their HA genes from the Asian H5N1 lineage were isolated from poultry during 2009-2010 in mainland China. Pathogenicity studies showed that these viruses were all highly virulent to chickens, while they varied from moderate to high virulence in mice and from mild to intermediate virulence in mallards. Phylogenetic analyses showed that these viruses were reassortants bearing the H5N1 backbone while acquiring PB1, NP and NA genes from unidentified non-H5N1 viruses, and had developed into three distinct genotypes (B-D). Molecular characterization indicated that all these viruses might resist to antiviral agents. Our findings highlight the emergence and development of HPAI H5 viruses of other NA subtypes in H5N1 endemic areas and their potential threat to poultry industry and public health. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：351 / 357

页数：7

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