Age-associated differences in immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to pneumococcal polysaccharides following vaccination

被引：66

作者：

Lottenbach, KR

Mink, CM

Barenkamp, SJ

Anderson, EL

Homan, SM

Powers, DC

机构：

[1] St Louis Univ, Hlth Sci Ctr, Dept Internal Med, Div Infect Dis & Immunol, St Louis, MO 63110 USA

[2] St Louis Univ, Ctr Vaccine Dev, St Louis, MO 63110 USA

[3] St Louis Univ, Sch Publ Hlth, St Louis, MO 63110 USA

[4] St Louis Univ, Sch Med, Dept Pediat, St Louis, MO 63104 USA

[5] Pediat Res Inst, St Louis, MO USA

[6] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[7] Eastern Virginia Med Sch, Glennan Ctr Geriatr & Gerontol, Norfolk, VA 23501 USA

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 09期

关键词：

D O I：

10.1128/IAI.67.9.4935-4938.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoglobulin G (IgG) subclass antibody responses to pneumococcal vaccines were determined for human subjects in four age groups. The ratios of IgG1/IgG2 antibody concentrations declined with advancing age for all five of the serotypes tested. Protein-conjugate vaccines elicited enhanced IgG antibody responses over plain polysaccharide vaccines in infants but not in adult groups.

引用

页码：4935 / 4938

页数：4

共 19 条

[1] Differences in the avidity of antibodies evoked by four different pneumococcal conjugate vaccines in early childhood [J].