Elements of cancer immunity and the cancer-immune set point

被引：3883

作者：

Chen, Daniel S. ^{[1
]}

Mellman, Ira ^{[1
]}

机构：

[1] Genentech Inc, 1 DNA Way, San Francisco, CA 94080 USA

来源：

NATURE | 2017年 / 541卷 / 7637期

关键词：

CELL LUNG-CANCER; CD8(+) T-CELLS; CHRONIC VIRAL-INFECTION; DEATH-LIGAND; TUMOR-INFILTRATING LYMPHOCYTES; CHECKPOINT-BLOCKADE; PD-1; BLOCKADE; CLINICAL ACTIVITY; MELANOMA PATIENTS; CTLA-4;

D O I：

10.1038/nature21349

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunotherapy is proving to be an effective therapeutic approach in a variety of cancers. But despite the clinical success of antibodies against the immune regulators CTLA4 and PD-L1/PD-1, only a subset of people exhibit durable responses, suggesting that a broader view of cancer immunity is required. Immunity is influenced by a complex set of tumour, host and environmental factors that govern the strength and timing of the anticancer response. Clinical studies are beginning to define these factors as immune profiles that can predict responses to immunotherapy. In the context of the cancer-immunity cycle, such factors combine to represent the inherent immunological status - or 'cancer- immune set point' - of an individual.

引用

页码：321 / 330

页数：10

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