The effect of selected parameters of formation on properties of alginate/Ca 2+/oligochitosan capsules

Optimization of the technological parameters affecting the mechanical properties and permeability of capsules is essential to produce capsules with improved properties for cell immobilization. In the present paper, the effect of different parameters on the technological properties of alginate/Ca2+/oligochitosan capsules has been investigated. The correct adjustment of the alginate concentration in the polymer matrix and the oligochitosan molar mass, concentration and coating time, have been found to be key parameters in obtaining porous and mechanically stable alginate/Ca2+/oligochitosan capsules. Results showed that an increase in the coating time and concentration of the alginate generated more stable capsules with a reduced membrane cut-off. Furthermore, we have established some correlations between capsule properties and the effectiveness of chitosan binding within the capsule's membrane. Data addressed herein could be a valid tool to fabricate optimized alginate/Ca2+/oligochitosan capsules with a potential for use in cell immobilization technology. (c) 2006 Society of Chemical Industry.