The type VI secretion system: translocation of effectors and effector-domains

被引：255

作者：

Pukatzki, Stefan ^{[1
]}

McAuley, Steven B. ^{[1
]}

Miyata, Sarah T. ^{[1
]}

机构：

[1] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2H7, Canada

来源：

CURRENT OPINION IN MICROBIOLOGY | 2009年 / 12卷 / 01期

基金：

加拿大健康研究院;

关键词：

RIBOSE-BINDING-PROTEIN; CROSS-LINKS ACTIN; PATHOGENICITY ISLAND; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; INTRACELLULAR GROWTH; EDWARDSIELLA-TARDA; VIRULENCE; IDENTIFICATION; GENES;

D O I：

10.1016/j.mib.2008.11.010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A number of prominent Gram-negative bacteria use the type VI secretion system (T6SS) to transport proteins across the bacterial envelope. Rapid progress is being made in elucidating the structural components of the T6SS apparatus, and a few effectors have been reported to pass through it. However, this is not the complete story: a family of T6SS proteins, the VgrGs, share structural features with the cell-puncturing device of the T4 bacteriophage, and may be used in a similar fashion by bacteria to puncture host cell membranes and insert the T6SS apparatus into the host cytosol. Interestingly, a number of VgrGs contain C-terminal extensions with effector-domains. Thus, the T6SS may translocate soluble effectors, as well as VgrG effector-domains.

引用

页码：11 / 17

页数：7

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