Stimulation of adenosine A(1) receptors prevents the EEG arousal due to dopamine D-1 receptor activation in rabbits

被引：20

作者：

Popoli, P ^{[1
]}

Ferre, S ^{[1
]}

Pezzola, A ^{[1
]}

Reggio, R ^{[1
]}

deCarolis, AS ^{[1
]}

Fuxe, K ^{[1
]}

机构：

[1] KAROLINSKA INST, DEPT NEUROSCI, DIV MOLEC & CELLULAR NEUROCHEM, S-17177 STOCKHOLM, SWEDEN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 305卷 / 1-3期

关键词：

dopamine D-1 receptor; adenosine A(1) receptor; EEG (electroencephalographic) arousal; (rabbit);

D O I：

10.1016/0014-2999(96)00242-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of adenosine A(1) (N-6-cyclopentyladenosine, CPA) and A(2) (2-[4-(2-carboxylethyl)phenethylamino]-5'-N-ethylcarbox-amido-adenosine hydrochloride, CGS 21680) receptor agonists on SKF 38393-induced electroencephalographic (EEG) arousal was studied in rabbits. While CPA (0.1 mg/kg i.v.) significantly prevented the EEG effects of SKF 38393, CGS 21680 (0.2 mg/kg i.v.) did not affect them. These results demonstrate that adenosine A(1) receptors can modulate dopamine D-1 receptor-induced EEG arousal and show, for the first time, that adenosine-dopamine interactions are involved in brain functions other than motor activity.

引用

页码：123 / 126

页数：4

共 20 条

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