γ-Glutamyltransferase and risk of stroke:: the EUROSTROKE project

被引:80
作者
Bots, ML
Salonen, JT
Elwood, PC
Nikitin, Y
de Concalves, AF
Inzitari, D
Sivenius, J
Trichopoulou, A
Tuomilehto, J
Koudstaal, PJ
Grobbee, DE
机构
[1] Univ Utrecht, Julius Ctr Patient Orineted Res, Med Ctr, NL-3584 CX Utrecht, Netherlands
[2] Erasmus Univ, Sch Med, Rotterdam, Netherlands
[3] Univ Kuopio, Publ Hlth Res Inst, FIN-70211 Kuopio, Finland
[4] Cardiff Univ, Ctr Appl Publ Hlth Med, Coll Med, Cardiff CF1 3NS, S Glam, Wales
[5] Russian Acad Med Sci, Siberian Branch, Inst Internal Med, Novosibirsk, Russia
[6] Hosp Univ Coimbra, Coimbra, Portugal
[7] Univ Florence, Florence, Italy
[8] Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland
[9] Univ Athens, Sch Med, Athens, Greece
[10] Natl Publ Hlth Inst, Helsinki, Finland
[11] Univ Hosp Rotterdam Dijkzigt, Rotterdam, Netherlands
关键词
D O I
10.1136/jech.56.suppl_1.i25
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: Alcohol consumption has been implicated in the aetiology of stroke. As data on alcohol consumption obtained by questionnaire are susceptible to missclassification, this study evaluated the assocation between gamma-glutomyltransferase (gamma-GT), as a marker for alcohol consumption, and fatal, non-fatal, haemorrhagic and ischaemic stroke in three European cohort studies, participating in EUROSTROKE. Methods: EUROSTROKE is a collaborative project among ongoing European cohort studies on incidence and risk factors of stroke. EUROSTROKE is designed as a nested case-control study. For each stroke case, two controls were sampled. Strokes were classified according to MONICA criteria or reviewed by a panel of four neurologists. At present, data on stroke and gamma-GT were available from cohorts in Cardiff (57 cases), Kuopio (66 cases), and Rotterdam (108 cases). Results: An increase in gamma-GT of one standard deviation (28.7 IU/ml) was associated with an age and sex adjusted 26% (95% CI 5 to 53) increase in risk of stroke. Adjustment for confounding variables such as drug use, history of myocardial infarction, total cholesterol, and diabetes mellitus did not materially attenuate the association. The risk of haemorrhagic stroke increased linearly with increase in gamma-GT. The association for cerebral infarction was not graded: the risk increased beyond the first quartile, and remained increased. The association of gamma-GT with stroke was significantly stronger among subjects without diabetes mellitus compared with subjects with diabetes mellitus (no association observed). Conclusion: This EUROSTROKE analysis showed that an increased gamma-GT, as a marker of alcohol consumption, is associated with increased risk of stroke, in particular haemorrhagic stroke.
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页码:I25 / I29
页数:5
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