Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation

被引：284

作者：

Morrissey, James H. ^{[1
]}

Choi, Sharon H. ^{[1
]}

Smith, Stephanie A. ^{[1
]}

机构：

[1] Univ Illinois, Dept Biochem, Urbana, IL 61801 USA

来源：

BLOOD | 2012年 / 119卷 / 25期

基金：

美国国家卫生研究院;

关键词：

FACTOR PATHWAY INHIBITOR; FACTOR-XI ACTIVATION; INORGANIC POLYPHOSPHATE; TISSUE FACTOR; CONTACT SYSTEM; STORAGE-POOL; PLASMA PREKALLIKREIN; BLOOD-COAGULATION; ESCHERICHIA-COLI; HAGEMAN-FACTOR;

D O I：

10.1182/blood-2012-03-306605

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inorganic polyphosphate is widespread in biology and exhibits striking prohemostatic, prothrombotic, and proinflammatory effects in vivo. Long-chain polyphosphate (of the size present in infectious microorganisms) is a potent, natural pathophysiologic activator of the contact pathway of blood clotting. Medium-chain polyphosphate (of the size secreted from activated human platelets) accelerates factor V activation, completely abrogates the anticoagulant function of tissue factor pathway inhibitor, enhances fibrin clot structure, and greatly accelerates factor XI activation by thrombin. Polyphosphate may have utility as a hemostatic agent, whereas antagonists of polyphosphate may function as novel antithrombotic/antiinflammatory agents. The detailed molecular mechanisms by which polyphosphate modulates blood clotting reactions remain to be elucidated. (Blood. 2012; 119(25): 5972-5979)

引用

页码：5972 / 5979

页数：8

共 114 条

[1]

[Anonymous], 2004, BIOCH INORGANIC POLY

[2] High sensitivity, quantitative measurements of polyphosphate using a new DAPI-Based approach [J].

Aschar-Sobbi, Roozbeh ;

Abramov, Andrey Y. ;

Diao, Catherine ;

Kargacin, Margaret E. ;

Kargacin, Gary J. ;

French, Robert J. ;

Pavlov, Evgeny .

JOURNAL OF FLUORESCENCE, 2008, 18 (05) :859-866

[3]

Asmis LM, 2008, SWISS MED WKLY, V138, P142, DOI 2008/09/smw-11788

[4]

Ault-Riché D, 1998, J BACTERIOL, V180, P1841

[5] Polyphosphate elicits pro-inflammatory responses that are counteracted by activated protein C in both cellular and animal models [J].

Bae, J. -S. ;

Lee, W. ;

Rezaie, A. R. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2012, 10 (06) :1145-1151

[6]

BenNasr A, 1996, MOL MICROBIOL, V20, P927

[7] STREPTOKINASE ACTIVATES PLASMINOGEN BOUND TO HUMAN GROUP-C AND GROUP-G STREPTOCOCCI THROUGH M-LIKE PROTEINS [J].

BENNASR, A ;

WISTEDT, A ;

RINGDAHL, U ;

SJOBRING, U .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 222 (02) :267-276

[8] The long and short of it - polyphosphate, PPK and bacterial survival [J].

Brown, Michael R. W. ;

Kornberg, Arthur .

TRENDS IN BIOCHEMICAL SCIENCES, 2008, 33 (06) :284-290

[9] Inorganic polyphosphate in the origin and survival of species [J].

Brown, MRW ;

Kornberg, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (46) :16085-16087

[10] TISSUE FACTOR PATHWAY INHIBITOR AND THE CURRENT CONCEPT OF BLOOD-COAGULATION [J].

BROZE, GJ .

BLOOD COAGULATION & FIBRINOLYSIS, 1995, 6 :S7-S13

← 1 2 3 4 5 6 7 8 9 10 →