Optical tomographic image reconstruction from ultrafast time-sliced transmission measurements

被引:53
作者
Cai, W [1 ]
Gayen, SK
Xu, M
Zevallos, M
Alrubaiee, M
Lax, M
Alfano, RR
机构
[1] CUNY, City Coll & Grad Ctr, Dept Phys,Inst Ultrafast Spect & Lasers, New York State Ctr Adv Technol Ultrafast Photon M, New York, NY 10031 USA
[2] CUNY, City Coll & Grad Ctr, Dept Elect Engn,Inst Ultrafast Spect & Lasers, New York State Ctr Adv Technol Ultrafast Photon M, New York, NY 10031 USA
关键词
D O I
10.1364/AO.38.004237
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Optical imaging and localization of objects inside a highly scattering medium, such as a tumor in the breast, is a challenging problem with many practical applications. Conventional imaging methods generally provide only two-dimensional (2-D) images of limited spatial resolution with little diagnostic ability. Here we present an inversion algorithm that uses time-resolved transillumination measurements in the form of a sequence of picosecond-duration intensity patterns of transmitted ultrashort light pulses to reconstruct three-dimensional (3-D) images of an absorbing object located inside a slab of a highly scattering medium. The experimental arrangement used a 3-mm-diameter collimated beam of 800-nm, 150-fs, 1-kHz repetition rate light pulses from a Ti:sapphire laser and amplifier system to illuminate one side of the slab sample. An ultrafast gated intensified camera system that provides a minimum FWHM gate width of 80 ps recorded the 2-D intensity patterns of the light transmitted through the opposite side of the slab. The gate position was varied in steps of 100 ps over a 5-ns range to obtain a sequence of 2-D transmitted. light intensity patterns of both less-scattered and multiple-scattered light for image reconstruction. The inversion algorithm is based on the diffusion approximation of the radiative transfer theory for photon transport in a turbid medium. It uses a Green's function perturbative approach under the Rytov approximation and combines a 2-D matrix inversion with a one-dimensional Fourier-transform inversion to achieve speedy 3-D image reconstruction. In addition to the lateral position, the method provides information about the axial position of the object as well, whereas the 2-D reconstruction methods yield only lateral position. (C) 1999 Optical Society of America.
引用
收藏
页码:4237 / 4246
页数:10
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