Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome

被引：60

作者：

Maeno, N ^{[1
]}

Takei, S ^{[1
]}

Imanaka, H ^{[1
]}

Yamamoto, K ^{[1
]}

Kuriwaki, K ^{[1
]}

Kawano, Y ^{[1
]}

Oda, H ^{[1
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Div Infect & Immun, Kagoshima 8908520, Japan

来源：

ARTHRITIS AND RHEUMATISM | 2004年 / 50卷 / 06期

关键词：

D O I：

10.1002/art.20268

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aberrant induction of proinflammatory cytokines is considered to be crucial in the pathogenesis of systemic juvenile idiopathic arthritis and adult-onset Still's disease. Interleukin-18 (IL-18) in particular has been reported to be a candidate for the key cytokine in both diseases; however, the origin of IL-18 is unclear. To clarify the origin, we investigated specimens from various organs obtained during autopsy of a child with systemic RA and macrophage activation syndrome, using immunohistochemical staining. Our results showed a high number of cells expressing IL-18 in the bone marrow but not in the other organs. This finding suggests that bone marrow is the origin of increased serum IL-18 and raises the possibility that other proinflammatory cytokines are also induced by IL-18 in bone marrow in this disease. Bone marrow may be an essential organ in the pathogenesis of systemic JIA.

引用

页码：1935 / 1938

页数：4

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