Montmorillonite clay catalyzed synthesis of functionalized pyrroles through domino four-component coupling of amines, aldehydes, 1,3-dicarbonyl compounds and nitroalkanes

被引：32

作者：

Bharate, Jaideep B. ^{[1
,2
]}

Sharma, Rajni ^{[2
,3
]}

Aravinda, Subrayashastry ^{[1
]}

Gupta, Vivek K. ^{[4
]}

Singh, Baldev ^{[2
,3
]}

Bharate, Sandip B. ^{[1
,2
]}

Vishwakarma, Ram A. ^{[1
,2
,3
]}

机构：

[1] CSIR, Indian Inst Integrat Med, Div Med Chem, Jammu 180001, India

[2] Acad Sci & Ind Res AcSIR, New Delhi 110001, India

[3] CSIR, Indian Inst Integrat Med, Nat Prod Chem Div, Jammu 180001, India

[4] Univ Jammu, Postgrad Dept Phys & Elect, Xray Crystallog Lab, Jammu 180001, India

来源：

RSC ADVANCES | 2013年 / 3卷 / 44期

关键词：

ONE-POT SYNTHESIS; HIGHLY EFFICIENT SYNTHESIS; SUBSTITUTED PYRROLES; 3-COMPONENT SYNTHESIS; REARRANGEMENT; CONDENSATION; LAMELLARINS; ALKALOIDS; ALCOHOLS; IMINES;

D O I：

10.1039/c3ra43324b

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

An efficient and eco-friendly synthesis of functionalized pyrroles using recyclable montmorillonite clay K10 and KSF catalysts has been described. The clay-catalyzed domino four-component coupling (4CC) of amines, aldehydes, 1,3-dicarbonyl compounds and nitroalkanes produced functionalized pyrroles in good yields. The developed methods offers advantages such as operational simplicity, economical, simple workup, use of commercial recyclable catalyst and excellent functional group compatibility to synthesize structurally diverse pyrroles. This is the first report on the use of heterogeneous catalyst for this 4CC.

引用

页码：21736 / 21742

页数：7

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