Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics

被引：53

作者：

Bonkowski, MS

Pamenter, RW

Rocha, JS

Masternak, MM

Panici, JA

Bartke, A

机构：

[1] So Illinois Univ, Sch Med, Dept Internal Med, Springfield, IL 62794 USA

[2] So Illinois Univ, Sch Med, Dept Physiol, Springfield, IL 62794 USA

[3] So Illinois Univ, Sch Med, Dept Internal Med Geriatr Res, Springfield, IL 62794 USA

[4] So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA

[5] So Illinois Univ, Sch Med, Dept Intenal Med Endocrinol & Metab, Springfield, IL 62794 USA

[6] So Illinois Univ, Sch Med, Dept Med Microbiol Immunol & Cell Biol, Springfield, IL 62794 USA

[7] Fed Univ Minas Gerais, Inst Biol Sci, Dept Morphol, Belo Horizonte, MG, Brazil

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2006年 / 61卷 / 06期

关键词：

D O I：

10.1093/gerona/61.6.562

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

There is conflicting information on the physiological role of growth hormone (GH) in the control of aging. This study reports dual-energy x-ray absorptiometry (DXA) measurements of body composition and bone characteristics in young, adult, and aged long-lived GH receptor knockout (GHR-KO) and normal mice to determine the effects of GH resistance during aging. Compared to controls, GHR-KO mice showed an increased percentage of body fat. GHR-KO mice have reduced total-body bone mineral density (BMD), bone mineral content, and bone area, but these parameters increased with age. In addition, GHR-KO mice have decreased femur length, femur BMD, and lower lumbar BMD compared to controls in all age groups. These parameters also continued to increase with age. Our results indicate that GH resistance alters body composition, bone growth, and bone maintenance during aging in GHR-KO mice.

引用

页码：562 / 567

页数：6

共 36 条

[1] Insulin-like growth factor-I and cognitive function in healthy older men [J].