Cells react to nanoscale order and symmetry in their surroundings

被引:227
作者
Curtis, ASG
Gadegaard, N
Dalby, MJ
Riehle, MO
Wilkinson, CDW
Aitchison, G
机构
[1] Univ Glasgow, Ctr Cell Engn, Glasgow G12 8QQ, Lanark, Scotland
[2] Univ Glasgow, Dept Elect & Elect Engn, Glasgow G12 8QQ, Lanark, Scotland
基金
英国生物技术与生命科学研究理事会;
关键词
cell adhesion; nano-order; nanopits; nanotopography; polycaprolactone (PCL); polymethylmethacrylate (PMMA); symmetry;
D O I
10.1109/TNB.2004.824276
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Mammalian cells react to microstructured surfaces, but there is little information on the reactions to nanostructured surfaces, and such as have been tested are poorly ordered or random in their structure. We now report that ordered surface arrays (orthogonal or hexagonal) of nanopits in polycaprolactone or polymethylmethacrylate have marked effects in reducing cell adhesion compared with less regular arrays or planar surfaces. The pits had diameters of 35, 75, and 120 nm, respectively, with pitch between the pits of 100, 200, and 300 nm, respectively. The cells appear to be able to distinguish between different symmetries of array. We suggest that interfacial forces may be organized by the nanostructures to affect the cells in the same way as they affect liquid crystal orientations.
引用
收藏
页码:61 / 65
页数:5
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