Improving drug biological effects by encapsulation into polymeric nanocapsules

被引：145

作者：

Frank, Luiza A. ^{[1
]}

Contri, Renata V. ^{[2
]}

Beck, Ruy C. R. ^{[1
,2
]}

Pohlmann, Adriana R. ^{[1
,2
,3
]}

Guterres, Silvia S. ^{[1
,2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Farmaceut, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Programa Posgrad Nanotecnol Farmaceut, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Dept Quim Organ, Porto Alegre, RS, Brazil

来源：

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2015年 / 7卷 / 05期

关键词：

LIPID-CORE NANOCAPSULES; INDOMETHACIN-LOADED NANOCAPSULES; VITRO ANTIOXIDANT ACTIVITY; PHYSICOCHEMICAL CHARACTERIZATION; ANTIPSYCHOTIC TREATMENT; TRETINOIN DEVELOPMENT; SUSTAINED-RELEASE; SKIN PENETRATION; NANOENCAPSULATION; DELIVERY;

D O I：

10.1002/wnan.1334

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

This review is based on selected reports from 2004 to 2014 and provides a comprehensive and updated overview of the state of the art related to the drug delivery advantages of polymeric nanocapsules, which are a specific type of polymeric nanoparticles used for improvement of biological effects. Special attention is given to the application of nanocapsules to increase the chemical and photostability of drugs, to modulate the interaction with cells and tissues, to reduce adverse effects of drugs, and to increase the drug efficiency and/or bioavailability. Moreover, this review covers in vitro and in vivo studies, highlighting interesting examples of drugs from several therapeutic classes for which efficacy is improved by encapsulation in different types of nanocapsules, especially in lipid-core nanocapsules. We also briefly present the first results obtained so far attesting to the safety of using polymeric nanocapsules for drug delivery. WIREs Nanomed Nanobiotechnol 2015, 7:623-639. doi: 10.1002/wnan.1334 For further resources related to this article, please visit the .

引用

页码：623 / 639

页数：17

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