Glycoside decoys of glycosylation

被引:6
作者
Brown, JR
Fuster, MM
Esko, JD
机构
[1] Univ Calif San Diego, Dept Cellular & Mol Med, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Med, Div Pulm Med, San Diego, CA 92103 USA
关键词
glycoside primers; disaccharides; cell adhesion; inhibitors; sialyl Lewis;
D O I
10.4052/tigg.13.335
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review focuses on glycosides that act as metabolic decoys and inhibitors of glycosylation. These compounds resemble metabolic intermediates and act as primers of glycan biosynthesis, diverting the synthesis of sugar chains from endogenous. glycoconjugates. Thus, glycosides inhibit glycoconjugate formation and provide a tool for studying glycan function in cells and whole organisms. Such primers may have future therapeutic potential through their ability to alter glycan-dependent pathologic processes in several disease states.
引用
收藏
页码:335 / 343
页数:9
相关论文
共 95 条
[1]  
Armstrong JI, 2000, ANGEW CHEM INT EDIT, V39, P1303, DOI 10.1002/(SICI)1521-3773(20000403)39:7<1303::AID-ANIE1303>3.0.CO
[2]  
2-0
[3]   Efficient preparation of natural and synthetic galactosides with a recombinant β-1,4-galactosyltransferase-/UDP-4′-gal epimerase fusion protein [J].
Blixt, O ;
Brown, J ;
Schur, MJ ;
Wakarchuk, W ;
Paulson, JC .
JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (07) :2442-2448
[4]   Chemo-enzymatic synthesis of fluorinated sugar nucleotide:: Useful mechanistic probes for glycosyltransferases [J].
Burkart, MD ;
Vincent, SP ;
Düffels, A ;
Murray, BW ;
Ley, SV ;
Wong, CH .
BIOORGANIC & MEDICINAL CHEMISTRY, 2000, 8 (08) :1937-1946
[5]  
CECCONI O, 1994, J BIOL CHEM, V269, P15060
[6]   Conversion of cellular sialic acid expression from N-acetyl- to N-glycolylneuraminic acid using a synthetic precursor, N-glycolylmannosamine pentaacetate: inhibition of myelin-associated glycoprotein binding to neural cells [J].
Collins, BE ;
Fralich, TJ ;
Itonori, S ;
Ichikawa, Y ;
Schnaar, RL .
GLYCOBIOLOGY, 2000, 10 (01) :11-20
[7]   CARBONOYLOXY ANALOGS OF THE ANTIMETASTATIC DRUG SWAINSONINE - ACTIVATION IN TUMOR-CELLS BY ESTERASES [J].
DENNIS, JW ;
WHITE, SL ;
FREER, AM ;
DIME, D .
BIOCHEMICAL PHARMACOLOGY, 1993, 46 (08) :1459-1466
[8]  
Dennis JW, 1999, BIOESSAYS, V21, P412, DOI 10.1002/(SICI)1521-1878(199905)21:5<412::AID-BIES8>3.0.CO
[9]  
2-5
[10]  
DING Y, 1995, ADV EXP MED BIOL, V376, P261