Relaxivity studies and X-ray structure of Gd(III)-diethylenetriamine-N,N′,N"-triacetic acid-N,N"-bis(2-methoxyphenethylamide) as a potential contrast agent for magnetic resonance imaging

被引：28

作者：

Wang, YM

Wang, YJ

Sheu, RS

Liu, GC

Lin, WC

Liao, JH

机构：

[1] Kaohsiung Med Coll, Sch Chem, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Coll, Dept Radiol, Kaohsiung 807, Taiwan

[3] Natl Chung Cheng Univ, Dept Chem, Chia I 621, Taiwan

来源：

POLYHEDRON | 1999年 / 18卷 / 8-9期

关键词：

paramagnetic gadolinium(III) complex; contrast agent; relaxivity; MRI;

D O I：

10.1016/S0277-5387(98)00406-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new bis(amide) derivative of diethylenetriamine-N,N,N',N",N"-pentaacetic acid (H(5)dtpa), diethylenetriamine-N,N',N"-triacelic-N,N"bis(2-methoxyphenethylamide) (H3L), has been synthesized. The crystal structure of gadolinium(III) complex of H3L ([GdL]) has been determined by X-ray crystallography. The coordination sphere of Gd(III) comprises three amine nitrogens, two amide oxygens, three carboxylic acid oxygens, and one water molecule. O-17 NMR shifts showed that the [DyL] complex had one inner-sphere water molecule. Relaxivity studies with the gadolinium(III) complex showed that they associate strongly with proteins leading to a significant relaxivity enhancement. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1147 / 1152

页数：6

共 24 条

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