Biology and physiology of Calbindin-D9k in female reproductive tissues: Involvement of steroids and endocrine disruptors

被引：37

作者：

Choi, KC

Leung, PCK

Jeung, EB ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Vet Med, Lab Vet Biochem & Mol Biol, Cheongju 361763, Chungbuk, South Korea

[2] Chungbuk Natl Univ, Vet Med Res Inst, Cheongju 361763, Chungbuk, South Korea

[3] Univ British Columbia, Child & Family Res Inst, British Columbia Childrens & Womens Hosp, Dept Obstet & Gynecol, Vancouver, BC V6H 3V5, Canada

来源：

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY | 2005年 / 3卷 / 1期

关键词：

D O I：

10.1186/1477-7827-3-66

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although Calbindin-D9k (CaBP-9k), a cytosolic calcium binding protein which has calcium binding sites, is expressed in various tissues, i.e., intestine, uterus, and placenta, potential roles of this gene and its protein are not clearly understood. Uterine CaBP-9k may be involved in controlling myometrial activity related with intracellular calcium level and is not under the control of vitamin D despite the presence of vitamin D receptors. But, it is under the control of the sex steroid hormones, estrogen (E2) and progesterone (P4), in female reproductive systems including the uterus and placenta. Thus, in this review, we summarize recent research literature in regards to the expression and regulation of CaBP-9k in mammals and introduce the research data of recent studies by us and others.

引用

页数：8

共 51 条

[1] Differential transcriptional and translational regulations of calbindin-D9k by steroid hormones and their receptors in the uterus of immature mice [J].