Oral Administration of Puerh Tea Polysaccharides Lowers Blood Glucose Levels and Enhances Antioxidant Status in Alloxan-Induced Diabetic Mice

被引：87

作者：

Xu, Ping ^{[1
,2
]}

Chen, Hao ^{[1
]}

Wang, Yiqi ^{[3
]}

Hochstetter, Danielle ^{[1
]}

Zhou, Tao ^{[1
]}

Wang, Yuefei ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Tea Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Chinese Minist Agr, Key Lab Hort Plant Growth Dev & Qual Improvement, Hangzhou 310029, Zhejiang, Peoples R China

[3] Zhejiang Chinese Med Univ, Coll Pharm, Hangzhou 310053, Zhejiang, Peoples R China

来源：

JOURNAL OF FOOD SCIENCE | 2012年 / 77卷 / 11期

关键词：

antioxidant; blood glucose; diabetes; polysaccharides; puerh tea; GREEN TEA; EXTRACTS;

D O I：

10.1111/j.1750-3841.2012.02950.x

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The polysaccharides, named puerh tea polysaccharides (PTPS), were isolated from puerh tea. Physicochemical characteristics, hypoglycemic and antioxidant effects of PTPS in alloxan-induced diabetic mice were investigated. PTPS was found to be a kind of acid heteropolysaccharides conjugate, but the physicochemical characteristics of which were different from the polysaccharides from other kinds of teas in literature. Meanwhile, daily administration of PTPS (40 mg/kg BW) could significantly lower the blood glucose levels, which was not different (P > 0.05) from the effects of metformin (15 mg/kg BW) throughout the entire experiment. Furthermore, after 4-wk administration of PTPS (40 mg/kg BW), the superoxide dismutase activity and malondialdehyde contents both in serum and liver were improved to the levels of those in normal mice. In regards to the serum GSH-Px activity, it was even significantly higher (P < 0.05) than that in normal mice, indicating the oxidative stress induced by alloxan could be reversed by administration of PTPS.

引用

页码：H246 / H252

页数：7

共 24 条

[1]

Physicochemical Properties and Antioxidant Capacity of 3 Polysaccharides from Green Tea, Oolong Tea, and Black Tea [J].