Cell death regulation by the mammalian IAP antagonist Diablo/Smac

被引:156
作者
Verhagen, AM [1 ]
Vaux, DL [1 ]
机构
[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
关键词
apoptosis; Diablo; Grim; HID; IAP; mitochondria; Reaper; Smac;
D O I
10.1023/A:1014318615955
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In Drosophila, the genetic locus 75CI1,2 is essential for all developmental cell death. Within this region are the genes for three pro-death proteins, Grim, Reaper and HID. These proteins are transcriptionally regulated and their expression tightly associated with cell death in the developing fly embryo. When ectopically expressed in the retina, Grim, Reaper and HID cause apoptosis and eye ablation. They have a short region of similarity at their N-termini through which they can interact with inhibitor of apoptosis (IAP) proteins, and it is by antagonising IAP inhibition of caspases that Grim, Reaper and HID promote cell death. The observation that Grim, Reaper and HID can interact with mammalian IAPs and induce apoptosis in mammalian cells suggested that mammalian IAP antagonists might also exist. Diablo/Smac, identified six years after the first description of a Drosophila IAP antagonist, is the only mammalian protein identified to date that is clearly functionally related to the Drosophila proteins. Since its discovery, there have been numerous studies investigating how Diablo/Smac interacts with IAPs and promotes cell death. Here we review what is currently known about Diablo/Smac and speculate on other mammalian IAP antagonists.
引用
收藏
页码:163 / 166
页数:4
相关论文
共 25 条
[1]   Structural basis of caspase-7 inhibition by XIAP [J].
Chai, JJ ;
Shiozaki, E ;
Srinivasula, SM ;
Wu, Q ;
Dataa, P ;
Alnemri, ES ;
Shi, YG .
CELL, 2001, 104 (05) :769-780
[2]   Structural and biochemical basis of apoptotic activation by Smac/DIABLO [J].
Chai, JJ ;
Du, CY ;
Wu, JW ;
Kyin, S ;
Wang, XD ;
Shi, YG .
NATURE, 2000, 406 (6798) :855-862
[3]   grim, a novel cell death gene in Drosophila [J].
Chen, P ;
Nordstrom, W ;
Gish, B ;
Abrams, JM .
GENES & DEVELOPMENT, 1996, 10 (14) :1773-1782
[4]   Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition [J].
Du, CY ;
Fang, M ;
Li, YC ;
Li, L ;
Wang, XD .
CELL, 2000, 102 (01) :33-42
[5]   DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9 [J].
Ekert, PG ;
Silke, J ;
Hawkins, CJ ;
Verhagen, AM ;
Vaux, DL .
JOURNAL OF CELL BIOLOGY, 2001, 152 (03) :483-490
[6]   THE HEAD INVOLUTION DEFECTIVE GENE OF DROSOPHILA-MELANOGASTER FUNCTIONS IN PROGRAMMED CELL-DEATH [J].
GRETHER, ME ;
ABRAMS, JM ;
AGAPITE, J ;
WHITE, K ;
STELLER, H .
GENES & DEVELOPMENT, 1995, 9 (14) :1694-1708
[7]   Structural basis of caspase inhibition by XIAP: Differential roles of the linker versus the BIR domain [J].
Huang, YH ;
Park, YC ;
Rich, RL ;
Segal, D ;
Myszka, DG ;
Wu, H .
CELL, 2001, 104 (05) :781-790
[8]   Identification of XAF1 as an antagonist of XIAP anti-caspase activity [J].
Liston, P ;
Fong, WG ;
Kelly, NL ;
Toji, S ;
Miyazaki, T ;
Conte, D ;
Tamai, K ;
Craig, CG ;
McBurney, MW ;
Korneluk, RG .
NATURE CELL BIOLOGY, 2001, 3 (02) :128-133
[9]   Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain [J].
Liu, ZH ;
Sun, CH ;
Olejniczak, ET ;
Meadows, RP ;
Betz, SF ;
Oost, T ;
Herrmann, J ;
Wu, JC ;
Fesik, SW .
NATURE, 2000, 408 (6815) :1004-1008
[10]   Structural basis for the inhibition of caspase-3 by XIAP [J].
Riedl, SJ ;
Renatus, M ;
Schwarzenbacher, R ;
Zhou, Q ;
Sun, CH ;
Fesik, SW ;
Liddington, RC ;
Salvesen, GS .
CELL, 2001, 104 (05) :791-800