Subset of senile dementia with high incidence of the apolipoprotein E epsilon 2 allele

被引:53
作者
Ikeda, K
Akiyama, H
Arai, T
Sahara, N
Mori, H
Usami, M
Sakata, M
Mizutani, T
Wakabayashi, K
Takahashi, H
机构
[1] TOKYO INST PSYCHIAT,DEPT MOL BIOL,TOKYO,JAPAN
[2] TOKYO METROPOLITAN INST GERONTOL,DEPT NEUROPATHOL,TOKYO,JAPAN
[3] NIIGATA UNIV,BRAIN RES INST,DEPT PATHOL,NIIGATA,JAPAN
关键词
D O I
10.1002/ana.410410522
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
There is a subset of very elderly patients with senile dementia in whom abundant neurofibrillary tangles are present, mainly in the hippocampal region, without a significant number of senile plaques. In a retrospective neuropathological examination of 239 dementia patients, 14 were found to have this type of senile dementia. The apolipoprotein E epsilon 2, epsilon 3, and epsilon 4 allele frequencies in this patient group were 0.39, 0.50, and O.11, respectively. Such a high frequency of the epsilon 2 allele suggests that this type of dementia is distinct from Alzheimer's disease not only from a neuropathological but also from a genetic viewpoint.
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页码:693 / 695
页数:3
相关论文
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