New developments in phospholipase A2

被引：18

作者：

Chaminade, B

Le Balle, F

Fourcade, O

Nauze, M

Delagebeaudeuf, C

Gassama-Diagne, A

Simon, MF

Fauvel, J

Chap, H ^{[1
]}

机构：

[1] Hop Purpan, INSERM U326, Ctr Hosp Univ Touluse, F-31059 Toulouse, France

[2] Univ Toulouse 3, Inst Federatif Rech Immunol Cellulaire & Mol, F-31058 Toulouse, France

来源：

LIPIDS | 1999年 / 34卷

关键词：

D O I：

10.1007/BF02562228

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some of the most recent data concerning Various phospholipases A(2), with special emphasis on secretory, cytosolic, and calcium-independent phospholipases A(2) are summarized. Besides their contribution to the production of proinflammatory lipid mediators, the involvement of these enzymes in key cell responses such as apoptosis or tumor cell metastatic potential is also discussed, taking advantage of transgenic models based on gene invalidation by homologous recombination; The possible role of secretory and cytosolic platelet-activating factor acetyl hydrolases is also briefly mentioned. Finally, the ectopic expression in epididymis of an intestinal phospholipase B opens some novel issues as: to the possible function of phospholipases in reproduction.

引用

页码：S49 / S55

页数：7

共 88 条

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[2]

2-Z

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