Outcomes of squamous cell cancer of the oral tongue managed at the princess margaret hospital

被引：29

作者：

Goldstein, David P. ^{[1
]}

Bachar, Gideon Y. ^{[1
]}

Lea, Jane ^{[1
]}

Shrime, Mark G. ^{[1
]}

Patel, Rajan S. ^{[1
]}

Gullane, Patrick J. ^{[1
]}

Brown, Dale H. ^{[1
]}

Gilbert, Ralph W. ^{[1
]}

Kim, John ^{[2
]}

Waldron, Jonathan ^{[2
]}

Perez-Ordonez, Bayardo ^{[3
]}

Davis, Aileen M. ^{[4
]}

Cheng, Lu ^{[5
]}

Xu, Wei ^{[5
]}

Irish, Jonathan C. ^{[1
]}

机构：

[1] Princess Margaret Hosp, Dept Otolaryngol Head & Neck Surg Surg Oncol, Wharton Head & Neck Program, Univ Hlth Network, Toronto, ON M5G 2M9, Canada

[2] Princess Margaret Hosp, Dept Radiat Oncol, Univ Hlth Network, Toronto, ON M5G 2M9, Canada

[3] Toronto Gen Hosp, Dept Pathol, Univ Hlth Network, Toronto, ON, Canada

[4] Univ Toronto, Toronto Western Res Inst, Univ Hlth Network, Toronto, ON, Canada

[5] Princess Margaret Hosp, Dept Biostat, Univ Hlth Network, Toronto, ON M5G 2M9, Canada

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2013年 / 35卷 / 05期

关键词：

tongue cancer; squamous cell carcinoma; oral cancer; treatment outcome; prognosis; LYMPH-NODE METASTASIS; PROGNOSTIC-FACTORS; TUMOR THICKNESS; IMPROVED SURVIVAL; PREDICTIVE-VALUE; INVASIVE FRONT; YOUNG-PATIENTS; LOCAL-CONTROL; STAGE-I; CARCINOMA;

D O I：

10.1002/hed.23001

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background The purpose of this study was to analyze the outcomes and treatment in patients with squamous cell carcinoma (SCC) of the oral tongue, as well as validate previously reported predictors of survival. Methods We retrospectively reviewed 259 patients treated with curative intent between 1994 and 2004. KaplanMeier estimates, log-rank test, and Cox regression models were used for statistical analysis. Results Two hundred fifty-nine patients were managed with surgery; 67 patients (25%) received adjuvant radiotherapy. Mean follow-up was 60 months. The 5-year local and regional control rates were 78% and 69.4%, respectively. The 5-year overall, disease-specific, and recurrence-free survival rates were 69%, 70.9%, and 53%, respectively. The only significant predictor of both overall survival (OS) and disease-free survival (DFS) on multivariable analysis was pathologic N classification. Conclusion Treatment of early tongue SCC effectively achieves local control and DFS. Nodal disease remains to be 1 of the most important prognostic factors in terms of recurrence and survival. (c) 2012 Wiley Periodicals, Inc. Head Neck, 2013

引用

页码：632 / 641

页数：10

共 54 条

[1] Treatment results and prognostic factors in oral tongue cancer: analysis of 80 patients [J].