A simple synthesis of 1-aminophosphonic acids from 1-hydroxyiminophosphonates with NaBH4 in the presence of transition metal compounds

被引：47

作者：

Demir, AS ^{[1
]}

Tanyeli, C ^{[1
]}

Sesenoglu, O ^{[1
]}

Demic, S ^{[1
]}

Evin, OO ^{[1
]}

机构：

[1] KARAELMAS UNIV,DEPT CHEM,ZONGULDAK 67100,TURKEY

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 03期

关键词：

D O I：

10.1016/0040-4039(95)02171-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new procedure has been developed for the synthesis of 1-aminophosphonic acids. Diethyl phosphonates are converted to hydroxyiminophosphonates when treated with hydroxylamine hydrochloride. Reduction of hydroxyiminophosphonates with NaBH4 in MeOH in the presence of MoO3 or NiCl2 and hydrolysis of 1- aminophosphonates gave 1-aminophosphonic acids in good yield.

引用

页码：407 / 410

页数：4

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