Association of malaria with inactivation of alpha 1,3-galactosyl transferase in catarrhines

被引：22

作者：

Ramasamy, R

Rajakaruna, R

机构：

[1] Molec. Biol. and Immunol. Labs., Division of Life Sciences, Institute of Fundamental Studies, Kandy, Hantana Road

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1997年 / 1360卷 / 03期

关键词：

anti-galactosyl antibody; alpha-galactosyl epitope; galactosyl transferase; malaria; primate evolution; (Plasmodium falciparum);

D O I：

10.1016/S0925-4439(97)00005-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Present-day catarrhines (old world monkeys and hominoids) lack Gal alpha 1-3 Gal beta 1-4 GlcNAc-R structures (alpha-galactosyl epitopes) and produce the corresponding anti-galactosyl antibodies (anti-gal), while platyrrhines (new world monkeys) and non-primate mammals possess alpha-galactosyl epitopes and lack anti-gal. Anti-gal is shown to inhibit Plasmodium falciparum growth in culture in a concentration dependent manner, probably by binding to alpha-galactosyl epitopes on merozoite surface molecules and causing complement mediated damage. A P. falciparum-like malaria parasite may therefore have selected for the inactivation of an alpha 1-3 galactosyl transferase in catarrhines. The implications of the results for the development of clinical immunity to falciparum malaria are briefly discussed.

引用

页码：241 / 246

页数：6

共 31 条

[1] THE DISTRIBUTION OF THE SICKLE-CELL TRAIT IN EAST AFRICA AND ELSEWHERE, AND ITS APPARENT RELATIONSHIP TO THE INCIDENCE OF SUBTERTIAN MALARIA [J].

ALLISON, AC .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1954, 48 (04) :312-318

[2]

BRUCECHWATT LJ, 1965, B WORLD HEALTH ORGAN, V32, P363

[3] SOUTH-AMERICAN MONKEYS IN THE DEVELOPMENT AND TESTING OF MALARIAL VACCINES - A REVIEW [J].

COLLINS, WE .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 1992, 87 :401-406

[4] MECHANISMS OF DEFENSE AGAINST PLASMODIUM-FALCIPARUM ASEXUAL BLOOD STAGES IN HUMANS [J].

DRUILHE, P ;

PERIGNON, JL .

IMMUNOLOGY LETTERS, 1994, 41 (2-3) :115-120

[5] AN EPITOPE RECOGNIZED BY INHIBITORY MONOCLONAL-ANTIBODIES THAT REACT WITH A 51 KILODALTON MEROZOITE SURFACE-ANTIGEN IN PLASMODIUM-FALCIPARUM [J].

EPPING, RJ ;

GOLDSTONE, SD ;

INGRAM, LT ;

UPCROFT, JA ;

RAMASAMY, R ;

COOPER, JA ;

BUSHELL, GR ;

GEYSEN, HM .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1988, 28 (01) :1-10

[6]

ESCALANTE AA, 1995, MOL BIOL EVOL, V12, P616

[7] PHYLOGENY OF THE MALARIAL GENUS PLASMODIUM, DERIVED FROM RIBOSOMAL-RNA GENE-SEQUENCES [J].

ESCALANTE, AA ;

AYALA, FJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (24) :11373-11377

[8]

Fleagle JG., 1988, PRIMATE ADAPTATION E, V2nd

[9]

Galili U, 1988, Transfus Med Rev, V2, P112, DOI 10.1016/S0887-7963(88)70037-1

[10]

GALILI U, 1988, J BIOL CHEM, V263, P17755

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