Positive correlation between levels of IL-1 or IL-2 and 1,25(OH)(2)D/25OH-D ratio in synovial fluid of patients with rheumatoid arthritis

被引:25
作者
Inaba, M [1 ]
Yukioka, K [1 ]
Furumitsu, Y [1 ]
Murano, M [1 ]
Goto, H [1 ]
Nishizawa, Y [1 ]
Morii, H [1 ]
机构
[1] YUKIOKA HOSP,KITA KU,OSAKA 530,JAPAN
关键词
vitamin D; rheumatoid arthritis; cytokine; synovial fluid;
D O I
10.1016/S0024-3205(97)00602-4
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The present study determined the levels in synovial fluid (SF) of vitamin D metabolites (1,25-dihydroxyvitamin D (1,25(OH)(2)D), 24,25-dihydroxyvitamin D (24,25(OH)(2)D) and 25-hydroxyvitamin D (25-OH-D)), and of the cytokines. We evaluated SF from 21 patients with rheumatoid arthritis (RA) and 6 patients with osteoarthritis (OA). The levels of vitamin D metabolites in SF, as determined by two different extraction methods, were significantly correlated (p < 0.05, n=7). The levels of 3 vitamin D metabolites were significantly higher in the RA SF than in OA SF (p < 0.05). The ratio of 1,25(OH)(2)D/25-OH-D in RA SF, which is presumed to reflect the activity of 25-OH-D-1-hydroxylase (1-OH-ase), was positively correlated with the levels of interleukin-1 alpha (IL-1 alpha), IL-1 beta, and IL-2 in such SF, and was significantly higher than that in sera from RA patients. This suggests an important role for these cytokines in the activation of 1-OH-ase in RA synovium. The ratio of 24,25(OH)(2)D/25-OH-D, which is presumed to reflect 25-OH-D-24-hydroxylase (24-OH-ase) activity, was significantly correlated with 1,25(OH)(2)D levels only in RA SF, but not in sera from RA patients, suggesting a local regulation of vitamin D metabolism that 1,25-(OH)(2)D induces 24-OH-ase as in other target cells. Our observations suggested that 1,25(OH)(2)D and 24,25(OH)(?)2D are produced locally from 25-OH-D in RA synovium, and that the syntheses of 1,25(OH)(2)D and 24,25(OH)(2)D may be affected by IL-1/IL-2 and 1,25(OH)(2)D in RA SF, respectively.
引用
收藏
页码:977 / 985
页数:9
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