Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the x-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus

被引：17

作者：

Fitz, W

Rosenthal, PB

Wong, CH

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

[2] HARVARD UNIV, DEPT MOL & CELLULAR BIOL, CAMBRIDGE, MA 02138 USA

[3] HARVARD UNIV, COMM HIGHER DEGREES BIOPHYS, CAMBRIDGE, MA 02138 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 08期

关键词：

D O I：

10.1016/0968-0896(96)00123-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2-alpha-Thiomethylmercuryl 9-acetamido-9-deoxy-sialoside was prepared and found to inhibit the 9-O-acetylsialic acid esterase from influenza C virus in a competitive manner with a K-i of 4.2 +/- 0.5 mM. The inhibitor is being used in the X-ray determination of the crystal structure of the esterase. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1349 / 1353

页数：5

共 35 条

[1]

AIR GM, 1983, GENETICS INFLUENZA V, pCH9

[2] INHIBITION OF THE FUSION-INDUCING CONFORMATIONAL CHANGE OF INFLUENZA HEMAGGLUTININ BY BENZOQUINONES AND HYDROQUINONES [J].