Asporin and knee osteoarthritis in patients of Greek origin

被引：60

作者：

Kaliakatsos, M.

Tzetis, M. ^{[1
]}

Kanavakis, E.

Fytili, P.

Chouliaras, G.

Karachalios, Th.

Malizos, K.

Tsezou, A.

机构：

[1] Univ Athens, Aghia Sophia Childrens Hosp, Dept Med Genet, GR-11527 Athens, Greece

[2] Univ Thessaly, Sch Med, Dept Orthoped, Larisa, Greece

[3] Univ Thessaly, Sch Med, Lab Cytogenet & Med Genet, Univ Hosp Larissa, Larisa, Greece

来源：

OSTEOARTHRITIS AND CARTILAGE | 2006年 / 14卷 / 06期

关键词：

asporin; osteoarthritis; association study;

D O I：

10.1016/j.joca.2005.10.012

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Ostearthritis (OA) is characterized by focal areas of loss of the articular cartilage in synovial joints, associated with varying degrees of osteophyte formation, subchondral bone change and synovitis. The Asporin (ASPN) gene which encodes a protein of the extracellular cartilage matrix contains a triplet repeat encoding for aspartic acid (D) within exon 2 The D14 allele was found associated with knee and hip osteoarthritis in case-control study in the Japanese population. Genotyping Greek knee CA patients for the D repeats we determined that the D15 allele could be considered a risk allele for our population. (c) 2005 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：609 / 611

页数：3

共 7 条

[1] Mice deficient in small leucine-rich proteoglycans:: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases [J].