Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population

被引：213

作者：

Kong, Xianglei ^{[1
,2
,3
,4
,5
]}

Ma, Yingchun ^{[1
,2
,3
,4
]}

Chen, Jianghua ^{[6
]}

Luo, Qiong ^{[7
]}

Yu, Xueqing ^{[8
]}

Li, Ying ^{[9
]}

Xu, Jinsheng ^{[10
]}

Huang, Songmin ^{[11
]}

Wang, Lining ^{[12
]}

Huang, Wen ^{[13
]}

Wang, Mei ^{[14
]}

Xu, Guobin ^{[15
]}

Zhang, Luxia ^{[1
,2
,3
,4
]}

Zuo, Li ^{[1
,2
,3
,4
]}

Wang, Haiyan ^{[1
,2
,3
,4
]}

机构：

[1] Peking Univ, Dept Med, Renal Div, Hosp 1, Beijing 100871, Peoples R China

[2] Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China

[3] Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China

[4] Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100871, Peoples R China

[5] Shandong Univ, Dept Nephrol, Qianfoshan Hosp, Jinan 250100, Peoples R China

[6] ZheJang Med Coll, Hosp 1, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China

[7] Peking Univ, ShenZhen Hosp, Dept Nephrol, Shenzhen, Peoples R China

[8] Sun Yat Sen Univ, Dept Nephrol, Hosp 1, Guangzhou 510275, Guangdong, Peoples R China

[9] HeBei Med Med Univ, Dept Nephrol, Hosp 3, Shijia Zhuang, Peoples R China

[10] HeBei Med Med Univ, Hosp 4, Dept Nephrol, Shijia Zhuang, Peoples R China

[11] Sichuan Univ, Dept Nephrol, Hua Xi Hosp, Chengdu 610064, Peoples R China

[12] China Med Univ, Dept Nephrol, Hosp 1, Shenyang, Peoples R China

[13] Capital Med Univ, Tong Ren Hosp, Dept Nephrol, Beijing, Peoples R China

[14] Peking Univ, Peoples Hosp, Dept Nephrol, Beijing 100871, Peoples R China

[15] Peking Univ, Dept Clin Lab, Hosp 1, Beijing 100871, Peoples R China

来源：

NEPHROLOGY DIALYSIS TRANSPLANTATION | 2013年 / 28卷 / 03期

关键词：

chronic kidney disease (CKD); eGFR equation; glomerular filtration rate (GFR); Tc-99m-DTPA; SERUM CREATININE; RENAL-DISEASE; GFR; PREVALENCE; DIET;

D O I：

10.1093/ndt/gfs491

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Previous studies have indicated that the performance of glomerular filtration rate (GFR) estimation equations vary according to the races of the target population. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has not been validated in the Chinese population including patients with chronic kidney disease (CKD) and healthy controls. A total of 977 adult persons (682 patients with CKD and 295 healthy volunteers) from nine renal institutes of university hospitals located in nine geographic regions of China were enrolled in the study. A diagnostic test study comparing the CKD-EPI two-level and four-level race equation, the Modification of Diet in Renal Disease (MDRD) Study equation and the modified MDRD equation for Chinese (the Chinese equation). The Tc-99m- diethylenetriamine pentaacetic acid dual plasma clearance was used as a reference method for measuring GFR. The mean age of participants was 48.3 16.0 years and 479 (49.0) were male. The CKD-EPI two-level race equation and the Chinese equation performed better than the MDRD Study equation and CKD-EPI four-level race equation, with less bias (median difference between estimated GFR and reference GFR, 0.2 and 0.3 versus 2.4 and 3.0 mL/min/1.73 m(2)), improved precision (interquartile range of the difference, 20.5 and 20.8 versus 23.4 and 20.5 mL/min/1.73 m(2)) and greater accuracy (percentage of estimated GFR within 30 of reference GFR, 73.4 and 73.0 versus 69.8 and 70.1). The CKD-EPI two-level race equation and the Chinese equation performed similarly in the Chinese population, and both performed better than the MDRD Study equation and the CKD-EPI four-level race equation.

引用

页码：641 / 651

页数：11

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