Sedation and Analgesia for the Mechanically Ventilated Patient

被引:45
作者
Brush, David R. [1 ]
Kress, John P. [1 ]
机构
[1] Univ Chicago, Med Ctr, Dept Med, Sect Pulm & Crit Care Med, Chicago, IL 60637 USA
关键词
Analgesics; Opioid administration and dosage; Conscious sedation methods; Critical Illness; Humans; Hypnotics and sedatives administration and dosage; Intensive care units; Respiration; Artificial; INTENSIVE-CARE-UNIT; CRITICALLY-ILL PATIENTS; POSTTRAUMATIC-STRESS-DISORDER; CONFUSION ASSESSMENT METHOD; RANDOMIZED-TRIAL; DAILY INTERRUPTION; INTERMITTENT LORAZEPAM; MONITORING SEDATION; MAJOR METABOLITE; ICU SEDATION;
D O I
10.1016/j.ccm.2008.09.001
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Mechanically ventilated patients in the intensive care unit routinely require sedative and analgesic medications to manage pain and anxiety. These medications may have unpredictable effects with long-term use. Strategies that may help to improve patient outcomes include thoughtful selection of medications, use of objective sedation and pain scales, and implementation of protocolized sedation.
引用
收藏
页码:131 / +
页数:12
相关论文
共 86 条
[1]   Propofol dosing regimens for ICU sedation based upon an integrated pharmacokinetic-pharmacodynamic model [J].
Barr, J ;
Egan, TD ;
Sandoval, NF ;
Zomorodi, K ;
Cohane, C ;
Gambus, PL ;
Shafer, SL .
ANESTHESIOLOGY, 2001, 95 (02) :324-333
[2]   Prolonged sedation of critically ill patients with midazolam or propofol: Impact on weaning and costs [J].
BarrientosVega, R ;
SanchezSoria, MM ;
MoralesGarcia, C ;
RobasGomez, A ;
CuenaBoy, R ;
AyensaRincon, A .
CRITICAL CARE MEDICINE, 1997, 25 (01) :33-40
[3]   Stress-inducing factors in ICUs: What liver transplant recipients experience and what caregivers perceive [J].
Biancofiore, G ;
Bindi, ML ;
Romanelli, AM ;
Urbani, L ;
Mosca, F ;
Filipponi, F .
LIVER TRANSPLANTATION, 2005, 11 (08) :967-972
[4]   Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment [J].
Breen, D ;
Wilmer, A ;
Bodenham, A ;
Bach, V ;
Bonde, J ;
Kessler, P ;
Albrecht, S ;
Shaikh, S .
CRITICAL CARE, 2004, 8 (01) :R21-R30
[5]   Decreased duration of mechanical ventilation when comparing analgesia-based sedation using remifentanil with standard hypnotic-based sedation for up to 10 days in intensive care unit patients: A randomised trial [ISRCTN47583497] [J].
Breen, D ;
Karabinis, A ;
Malbrain, M ;
Morais, R ;
Albrecht, S ;
Jarnvig, IL ;
Parkinson, P ;
Kirkham, AJ .
CRITICAL CARE, 2005, 9 (03) :R200-R210
[6]   Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation [J].
Brook, AD ;
Ahrens, TS ;
Schaiff, R ;
Prentice, D ;
Sherman, G ;
Shannon, W ;
Kollef, MH .
CRITICAL CARE MEDICINE, 1999, 27 (12) :2609-2615
[7]   A randomized trial of pyotocol-directed sedation management for mechanical ventilation in an Australian intensive care unit [J].
Bucknall, Tracey K. ;
Manias, Elizabeth ;
Presneill, Jeffrey J. .
CRITICAL CARE MEDICINE, 2008, 36 (05) :1444-1450
[8]   ACCUMULATION OF MIDAZOLAM AFTER REPEATED DOSAGE IN PATIENTS RECEIVING MECHANICAL VENTILATION IN AN INTENSIVE-CARE UNIT [J].
BYATT, CM ;
LEWIS, LD ;
DAWLING, S ;
COCHRANE, GM .
BRITISH MEDICAL JOURNAL, 1984, 289 (6448) :799-800
[9]   Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients [J].
Cammarano, WB ;
Pittet, JF ;
Weitz, S ;
Schlobohm, RM ;
Marks, JD .
CRITICAL CARE MEDICINE, 1998, 26 (04) :676-684
[10]   A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients [J].
Carson, SS ;
Kress, JP ;
Rodgers, JE ;
Vinayak, A ;
Campbell-Bright, S ;
Levitt, J ;
Bourdet, S ;
Ivanova, A ;
Henderson, AG ;
Pohlman, A ;
Chang, L ;
Rich, PB ;
Hall, J .
CRITICAL CARE MEDICINE, 2006, 34 (05) :1326-1332